Evidence map›Paper›PMID 36544813›Full record

ArticleCurrent research in pharmacology and drug discovery2023

Characterization of a novel positive allosteric modulator of the α

Robert S Papay, Jonathan D Macdonald, Shaun R Stauffer, Dianne M Perez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in pharmacology and drug discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Structural Perspectives on Biased Allostery of GPCR Signaling.Handbook of experimental pharmacology · 2026
    Review
  2. Article
  3. Regulation of non-emotional memory through αIBRO neuroscience reports · 2025
    Review
  4. Article
  5. αInternational journal of molecular sciences · 2023
    Review
  6. A PAM of the αCurrent research in pharmacology and drug discovery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert S PapayThe Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Jonathan D MacdonaldCenter for Therapeutics Discovery, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Shaun R StaufferCenter for Therapeutics Discovery, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Dianne M PerezThe Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Cleveland Clinic · US

Funding

Early Stage Studies of a Novel Positive Allosteric Modulator of the Alpha1-Adrenergic Receptor to Treat Alzheimer's DiseaseR01AG066627 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI PEREZ, DIANNE M · 2020 to 2024
$2.0M
Alpha1A-Adrenoceptors in CognitionR03AG049394 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI PEREZ, DIANNE M · 2015 to 2016
$159k
NIA NIH HHS R01 AG066627NIA NIH HHS R03 AG049394
6 · The paper itself

Abstract

α

Indexed as

alpha1-adrenergic receptorNorepinephrinePositive allosteric modulator

Identifiers

PMID36544813
PMCPMC9762201
OpenAlexW4311297055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.