Evidence map›Paper›PMID 36544491›Full record

ArticleFrontiers in genetics2022

Inflammation-related pathways involved in damaged articular cartilage of rats exposed to T-2 toxin based on RNA-sequencing analysis.

Longyan Shi, Qiuliang Liu, Heying Yang, Qi Wang, Jiaxiang Wang, Yingzhong Fan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Longyan ShiDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Qiuliang LiuDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Heying YangDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Qi WangDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Jiaxiang WangDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yingzhong FanDepartment of Pediatric Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have shown that ingestion of the T-2 toxin is harmful to articular cartilage. However, the mechanisms underlying damaged articular cartilage induced by T-2 toxin have not been elucidated. Twenty-four SD rats were randomly divided into T-2 toxin and control groups. In the control group, the 12 rats were administered 4% absolute ethanol by gavage, and in the T-2 toxin group, the 12 rats were administered T-2 toxin (100 ng/g, BW/day) by gavage. After the rats were sacrificed, the knee joints were collected, and RNA was extracted using TRIzol reagent for RNA sequencing (RNA-seq). Differentially expressed mRNA was identified based on

Indexed as

articular cartilageIL-17 signaling pathwayinflammatory responseRNA-seqT-2 toxinTNF signaling pathway

Identifiers

PMID36544491
PMCPMC9760703
OpenAlexW4310672731

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.