Evidence map›Paper›PMID 36544422›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2022

[Effect of inhibiting miR-204 expression on the learning and memory abilities of neonatal rats with intrauterine growth restriction and related mechanism].

Dong-Liang Zhu, Hong-Xia Yan, Jian-Jun Yue, Jian-Feng Liu, Zeng-Bo Li, Jing-Fang Song

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Dong-Liang Zhu, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.
Hong-Xia Yan, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.
Jian-Jun Yue, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.
Jian-Feng Liu, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.
Zeng-Bo Li, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.
Jing-Fang Song, Department of Pediatrics, Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang,Hunan ,421001,China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect of inhibiting miR-204 expression on the learning and memory abilities of neonatal rats with intrauterine growth restriction (IUGR) and related mechanism.

methodsA rat model of IUGR was prepared by low-protein diet. The 3-day-old IUGR rats were divided into three groups: model, miRNA antagonist control and miR-204 antagonist, with 10 rats in each group. Ten normal neonatal rats served as the control group. Morris water maze test was used to measure the learning and memory abilities of the rats. Quantitative real-time PCR was used to measure the mRNA expression levels of miR-204 and brain-derived neurotrophic factor (BDNF) in the hippocampus. Nissl staining and TUNEL staining were used to observe the number of Nissl bodies and the apoptosis of cells in the hippocampus. Western blot was used to measure the expression levels of BDNF/TrkB signaling pathway-related proteins in the hippocampus.

resultsCompared with the control group, the model group had a significant increase in the escape latency and a significant reduction in the number of platform crossings (

conclusionsInhibiting miR-204 can improve the learning and memory functions of neonatal rats with IUGR, possibly by targeted activation of the BDNF/TrkB signaling pathway.

Indexed as

Brain-Derived Neurotrophic FactorFetal Growth RetardationLearningMemoryMicroRNAsAnimalsAnimals, NewbornFemaleHippocampusMaze LearningRatsRats, Sprague-DawleyReceptor, trkBRNA, MessengerBrain-Derived Neurotrophic FactorMicroRNAsMIRN204 microRNA, ratReceptor, trkBRNA, MessengerBDNF/TrkB signaling pathwayIntrauterine growth restrictionLearning and memory abilitymiR-204Neonatal rat

Identifiers

PMID36544422
PMCPMC9785090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.