Evidence map›Paper›PMID 36544385›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2023

Reduced D

Alison R Weiss, Daniele Bertoglio, William A Liguore, Kristin Brandon, John Templon, Jeanne Link, Jodi L McBride

Open access · greenAbstract read
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alison R Weiss *Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA.ORCID 0000-0002-1821-8193
Daniele Bertoglio *Molecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-4205-5432
William A LiguoreDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA.
Kristin BrandonDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA.
John TemplonDivision of Cardiometabolic Health, Oregon National Primate Research Center, Beaverton, Oregon, USA.
Jeanne LinkCenter for Radiochemistry Research, OHSU Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Jodi L McBrideDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA.ORCID 0000-0002-4816-7569
Oregon National Primate Research Center · USOregon Health & Science University · USUniversity of Antwerp · BE

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Neuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3M
Cortico-basal ganglia connectivity in a non-human primate model of Huntington's diseaseR01NS099136 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCBRIDE, JODI L. · 2016 to 2020
$3.1M
Limbic-basal ganglia connectivity in a non-human primate model of Huntington's diseaseF32NS110149 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI WEISS, ALISON RUTH · 2018 to 2019
$103k
NIA NIH HHS T32 AG055378NIH HHS F32NS110149NIH HHS P51 OD011092NIH HHS R01NS099136NIH HHS T32AG055378NINDS NIH HHS F32 NS110149NINDS NIH HHS R01 NS099136
6 · The paper itself

Abstract

backgroundDopamine system dysfunction and altered glucose metabolism are implicated in Huntington's disease (HD), a neurological disease caused by mutant huntingtin (mHTT) expression.

objectiveThe aim was to characterize alterations in cerebral dopamine D

methodsPositron emission tomography (PET) imaging was performed using [

resultsCompared to controls, HD macaques showed significantly reduced dopamine D

conclusions[

Indexed as

Fluorodeoxyglucose F18Huntington DiseaseAnimalsBenzamidesDopamineGlucoseMacacaPositron-Emission TomographyReceptors, Dopamine D3BenzamidesDopaminefallyprideFluorodeoxyglucose F18GlucoseReceptors, Dopamine D32-[18F]fluoro-2-deoxy-d-glucosebinding potentialcortical-basal gangliafallypridepositron emission tomography imaging

Identifiers

PMID36544385
PMCPMC9948637
OpenAlexW4312072215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.