ArticleBMC public health2022
Cigarette smoking during pregnancy and adverse perinatal outcomes: a cross-sectional study over 10 years.
Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Maternal risk factors associated with neonatal necrotizing enterocolitis: a meta-analysis and systematic review.BMC pediatrics · 2026Pooled it
- A systematic review of couple- or household-targeted interventions for smoking cessation in pregnancy.BMC public health · 2026Pooled it
- Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.Neuroradiology · 2025Pooled it
- Magnitude and risk factors of khat, alcohol and cigarettes use among pregnant women in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Nanomolar vanillin, an e-cigarette flavorant, appears to disrupt pluripotency and promote endodermal differentiation in human embryonic stem cells via TRPV4 activation.Human reproduction (Oxford, England) · 2026Article
- Effects of Maternal Cigarette Smoking on Pulmonary Function, Respiratory Muscle Strength, Functional Exercise Capacity, and Skeletal Muscle Oxygenation During the Second Trimester of Pregnancy.Medicina (Kaunas, Lithuania) · 2026Article
- Smoking cessation intervention for Indigenous pregnant women: A systematic review of randomized controlled trials.Preventive medicine reports · 2026Review
- Cardiometabolic Health in Pregnancy: Prevention, Management, and Long-Term Implications.JACC. Advances · 2026Review
- Maternal smoking during pregnancy and gestational diabetes mellitus: Interactions and independent associations on pregnancy duration and perinatal outcomes.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Impact of Secondhand Smoke on the Biomineralization of Dental Enamel in Rats.Calcified tissue international · 2026Article
- Changes in Antenatal Obstetric Hospitalizations During the COVID-19 Pandemic in Western Sydney, Australia: A Population-Based Study.Maternal and child health journal · 2026Article
- Cannabis Exposure After Pregnancy and Development of Hypertension in the nuMoM2b Heart Health Study.O&G open · 2026Article
- Perinatal outcomes of pregnant adolescents in rural Japan: a retrospective cohort study at a comprehensive perinatal center.BMC pregnancy and childbirth · 2026Article
- Periconceptual Caffeine Intake and Adverse Pregnancy Outcomes: Results From the nuMoM2b Cohort.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Food, Built and Socio-Economic Environments and Maternal-Infant Outcomes: A Geospatial and Structural Equation Modelling of 163 000 Births.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Association of adverse pregnancy outcomes and intimate partner violence survivorship: a cross-sectional survey.Frontiers in global women's health · 2026Article
- Prenatal Cannabis and Tobacco: Studies in Animal Models.Advances in experimental medicine and biology · 2026Review
- Maternal Smoking During Pregnancy and Risk of Autism Spectrum Disorder in Offspring: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- How long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.Journal of Crohn's & colitis · 2025Article
- Targeted Analysis of Placental Steroid Hormones in Relation to Maternal Tobacco Smoke Exposure: Early Markers Relevant to DOHaD (Developmental Origins of Health and Disease).International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been shown that active exposure to tobacco is associated with adverse pregnancy outcomes including, but not limited to, intrauterine fetal death, reduced fetal weight, and higher risk of preterm birth. We want to investigate these effects in a high-income country.
methodsThis cross-sectional study examined 20,843 pregnant women who delivered over 10 years at the Maternity Hospital of the Centre Hospitalier Universitaire Vaudois (CHUV) in Lausanne, Switzerland. The objective was to evaluate a dose-response relationship between daily cigarette use during pregnancy and possible adverse perinatal outcomes. The social and clinical characteristics as well as obstetric and neonatal outcomes were compared between the smoking and the non-smoking groups. Adjusted odds ratios (aOR) and trend analyses (p
resultsNineteen thousand five hundred fifty-four pregnant women met the inclusion criteria and 2,714 (13.9%) of them were smokers. Even after adjusting for confounding factors, smoking during pregnancy was associated with preterm birth, birthweight < 2500 g, intrauterine growth restriction, neonatal respiratory and gastrointestinal diseases, transfer to the neonatal intensive care unit, and neonatal intensive care unit admissions > 7 days. Intrauterine death and neonatal infection were associated with heavy smoking (≥ 20 cigarettes/day). Smoking appeared to be a protective factor for pre-eclampsia and umbilical cord arterial pH below 7.1. A significant trend (p
conclusionCigarette smoking is associated with several adverse perinatal outcomes of pregnancy with a dose-dependent effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.