ArticleNature2023
R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 188 papers.
0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed
23.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
188 citing papers in PubMed, 280 citations in OpenAlex.
- TREX1 limits anti-tumor immunity by degrading short cytosolic DNA molecules.EMBO reports · 2026Article
- Article
- Viral mimicry escape as a necessary feature of malignant transformation.Nature reviews. Cancer · 2026Review
- The DNA/RNA Helicase SETX Maintains R-Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer.Cancer science · 2026Article
- Review
- Castration-resistant prostate cancer cells are addicted to the high activity of cyclin-dependent kinase 2.Molecular oncology · 2026Article
- Biosensor reveals unexpected variability in the cGAS response to DNA damage.Nature cell biology · 2026Article
- A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability.Nature cell biology · 2026Article
- The DNA damage response and cancer immunotherapy.Nature reviews. Cancer · 2026Review
- Systematic methodological flaws in DNA contamination assessment of mRNA vaccines: A critical analysis of Achs et al. (2025).Oncotarget · 2026Article
- SIRT1 Inhibits T-cell Infiltration and Tertiary Lymphoid Structure Formation to Promote Radioimmunotherapy Resistance.Cancer research · 2026Article
- PAF1c depletion confers chemoresistance to topoisomerase inhibitors.Cell insight · 2026Article
- The role of non-coding RNAs in regulating R-loop dynamics in cancer: Mechanisms and therapeutic implications.Acta pharmaceutica Sinica. B · 2026Review
- BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells.Neoplasia (New York, N.Y.) · 2026Article
- Article
- R-loops and D-loops: a delicate balance in genomic stability and instability.Cell communication and signaling : CCS · 2026Review
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- NAT10-dependent NCell reports · 2026Article
- The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR.iScience · 2026Article
- Multi-omics dissection of R-loop dynamics in tumorigenesis: From transcription-replication conflict to therapeutic targets.Molecular therapy. Oncology · 2026Review
128 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 3 countries.
Magdalena P Crossley *Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Chenlin Song *Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Michael J BocekDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Jun-Hyuk ChoiDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2271-949X
Joseph N KousourosDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Ataya SathirachindaDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Cindy LinDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Joshua R BricknerDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Gongshi BaiDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Hannes LansDepartment of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4417-5358
Wim VermeulenDepartment of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3616-734X
Monther Abu-RemailehDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Karlene A CimprichDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, USA. cimprich@stanford.edu.ORCID http://orcid.org/0000-0002-1937-2969
Stanford University · USErasmus MC · NLKorea Research Institute of Standards and Science · KRStanford Medicine · US
Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MLeveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1MTranscription-Associated Genome InstabilityR01GM119334 · NIGMS · STANFORD UNIVERSITY · PI Karlene A Cimprich · 2016 to 2026
$4.0MInnovations and mechanisms in tumor subcellular metabolismDP2CA271386 · NCI · STANFORD UNIVERSITY · PI ABU-REMAILEH, MONTHER · 2021 to 2024
$2.4MCOMPUTATIONAL METHODS FOR PROTEOMIC ANALYSISK22HG000044 · NHGRI · UNIVERSITY OF UTAH · PI GIDDINGS, MORGAN CORINNE · 2000 to 2005
$1.3MHigh Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596kNCI NIH HHS DP2 CA271386NCI NIH HHS T32 CA009302NHGRI NIH HHS K22 HG000044NHGRI NIH HHS T32 HG000044NHGRI NIH HHS T32-HG000044NIGMS NIH HHS R01 GM119334NIH HHS S10 OD018220
Abstract
R-loops are RNA-DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability
Indexed as
CytoplasmDNAInnate Immunity RecognitionNucleic Acid HeteroduplexesR-Loop StructuresRNAApoptosisCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA-Binding ProteinsDNA Excision Repair Protein ERCC-5DNA HelicasesGenes, BRCA1HumansInterferon Regulatory Factor-3Multifunctional EnzymesMutationcGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNADNA-Binding ProteinsDNA Excision Repair Protein ERCC-5DNA HelicasesInterferon Regulatory Factor-3IRF3 protein, humanMultifunctional EnzymesNucleic Acid HeteroduplexesRNARNA HelicasesSETX protein, humanTLR3 protein, humanToll-Like Receptor 3xeroderma pigmentosum group F protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.