ArticleNature cell biology2023
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.
Open access · hybridAbstract read
In one paragraph
Article in Nature cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Metabolic stress remodels the Golgi-sphingolipid-lipid droplet axis in INS-1E β-cells: an integrated molecular signature of early β-cell vulnerability.Molecular biology reports · 2026Article
- Spatially resolved lipid compartmentalization in human pancreatic islets revealed by high-resolution ultra-low-flow-rate desorption electrospray ionization mass spectrometry imaging.Analytical and bioanalytical chemistry · 2026Article
- Mitochondria-associated programmed cell death in pancreatic β cell of T2DM.Apoptosis : an international journal on programmed cell death · 2026Review
- Detergents without a drain: the evolutionary logic (and liability) of sphingolipids.Journal of lipid research · 2026Review
- Stress-driven remodeling of antigen presentation and chemokine signaling in pancreatic β-cells: implications for type 1 diabetes.Frontiers in immunology · 2026Review
- Noncovalent crown ether-assisted separation of stereoisomeric glycosphingosines using cyclic ion mobility spectrometry.Analytical and bioanalytical chemistry · 2025Article
- Secretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling.Structure (London, England : 1993) · 2025Article
- Impact of Nutrition on Sphingolipid-Regulated Physiology: A Review.Molecular nutrition & food research · 2025Review
- Dynamic multi-omics profiling of islet and gut hormonal secretion and peripheral crosstalk in response to various nutrient loads.Cell reports. Medicine · 2025Article
- Article
- Serum sphingomyelin levels define oxyhemoglobin desaturation-related metabolic threshold in symptomatic obstructive sleep apnea.Scientific reports · 2025Observational
- Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's Disease and Type 2 Diabetes: The Truth and Mystery.Journal of cellular and molecular medicine · 2025Review
- Reduced circulating sphingolipids andScience advances · 2025Article
- Early Postpartum Metabolic Heterogeneity Among Women Who Progressed to Type 2 Diabetes After Gestational Diabetes: A Prospective Cohort.Diabetes/metabolism research and reviews · 2025Article
- Regulation of cellular and systemic sphingolipid homeostasis.Nature reviews. Molecular cell biology · 2024Review
- A functional variant rs912304 for late-onset T1D risk contributes to islet dysfunction by regulating proinflammatory cytokine-responsive gene STXBP6 expression.BMC medicine · 2024Article
- Ceramides are fuel gauges on the drive to cardiometabolic disease.Physiological reviews · 2024Review
- Urinary sphingolipids in adolescents and young adults with youth-onset diabetes.Pediatric nephrology (Berlin, Germany) · 2024Article
- Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024Article
- Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis.The Journal of cell biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 9 institutions in 3 countries.
Kerstin Griess *Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-6672-2394
Michael Rieck *Institute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-7837-1130
Nadine MüllerInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-4760-6144
Gergely KarsaiCenter for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-6840-682X
Sonja HartwigGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-5225-6804
Angela PelligraInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-3775-8117
Robert HardtInstitute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2939-7657
Caroline SchlegelInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Jennifer KubothInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Celina UhlemeyerInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-8772-1799
Sandra TrenkampGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Kay JeruschkeGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Jürgen WeissGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Leon Peifer-WeissInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-2391-1937
Weiwei XuGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Sandra CamesGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Xiaoyan YiULB Center for Diabetes Research, Medical Faculty, Université Libre De Bruxelles, Brussels, Belgium.
Miriam CnopULB Center for Diabetes Research, Medical Faculty, Université Libre De Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0002-5112-1692
Mathias BellerInstitute for Mathematical Modeling of Biological Systems and Systems Biology of Lipid Metabolism, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-0987-0080
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-3336-1710
Arun Kumar KondadiInstitute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-5888-7834
Andreas S ReichertInstitute of Biochemistry and Molecular Biology I, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0001-9340-3113
Daniel MarkgrafGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Marianne WammersDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Dieter HäussingerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-5936-682X
Oliver KussGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Stefan LehrGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3971-357X
Decio EizirikULB Center for Diabetes Research, Medical Faculty, Université Libre De Bruxelles, Brussels, Belgium.
Heiko LickertGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4597-8825
Eckhard LammertInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Michael RodenGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID http://orcid.org/0000-0001-8200-6382
Dominic WinterInstitute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-6788-6641
Hadi Al-HasaniGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Doris HöglingerHeidelberg University Biochemistry Center, Heidelberg, Germany.
Thorsten HornemannCenter for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4218-1087
Jens C BrüningDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
Bengt-Frederik BelgardtInstitute for Vascular and Islet Cell Biology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. bengt.belgardt@ddz.de.ORCID http://orcid.org/0000-0003-4537-9002
Deutsches Diabetes-Zentrum e.V. · DEHeinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DEUniversité Libre de Bruxelles · BEHelmholtz Zentrum München · DEUniversity of Bonn · DEUniversity of Zurich · CHHeidelberg University · DEUniversity of Cologne · DE
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 278001972 - TRR186Deutsche Forschungsgemeinschaft (German Research Foundation) INST 208/760-1FUGGDeutsche Forschungsgemeinschaft (German Research Foundation) RTG2576EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 759099
Abstract
Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both type 1 diabetes and type 2 diabetes (T2D) (refs.
Indexed as
Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Insulin-Secreting CellsCarrier ProteinsGlucoseHomeostasisHumansInsulinProinsulinSphingolipidsCarrier ProteinsGlucoseInsulinProinsulinSphingolipids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.