Evidence map›Paper›PMID 36543808›Full record

ArticleScientific reports2022

A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.

Ah Ra Do, Jin An, Jinyeon Jo, Woo Jin Kim, Hae Yeon Kang, Sanghun Lee, Dankyu Yoon, You Sook Cho, Ian M Adcock, Kian Fan Chung and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025
    Review
  2. Article
  3. Asthma-Genomic Advances Toward Risk Prediction.Clinics in chest medicine · 2024
    Review
  4. Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Ah Ra Do *Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, South Korea.
Jin An *Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, South Korea.
Jinyeon JoDepartment of Public Health Sciences, School of Public Health, Seoul National University, Kwanak-ro 1, Kwanak-gu, Seoul, 151-742, Korea.
Woo Jin KimDepartment of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, South Korea.
Hae Yeon KangDepartment of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.
Sanghun LeeDeptartment of Medical Consilience, Division of Medicine, Graduate School, Dankook University, Yongin, South Korea.
Dankyu YoonDivision of Allergy and Respiratory Disease Research, Department of Chronic Disease Convergence Research, National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Korea.
You Sook ChoDepartment of Internal Medicine, Division of Allergy and Clinical Immunology, Asan Medical Center, Ulsan University School of Medicine, Seoul, South Korea.
Ian M AdcockExperimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Kian Fan ChungExperimental Studies, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Sungho Won *Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, South Korea. sunghow@gmail.com.ORCID 0000-0001-5751-5089
Tae-Bum Kim *Department of Internal Medicine, Division of Allergy and Clinical Immunology, Asan Medical Center, Ulsan University School of Medicine, Seoul, South Korea. tbkim@amc.seoul.kr.ORCID 0000-0001-5663-0640
Seoul National University · KRAsan Medical Center · KRImperial College London · GBDankook University · KRKangwon National University · KRKorea Disease Control and Prevention Agency · KRKyung Hee University Hospital at Gangdong · KRSeoul National University Hospital · KR

Funding

Medical Research Council MC_PC_17228Medical Research Council MR/T010371/1
6 · The paper itself

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors. This study aimed to identify novel genes underlying both asthma and COPD using genome-wide association study (GWAS) to differentiate between the two diseases. We performed a GWAS of asthma and COPD in 7828 Koreans from three hospitals. In addition, we investigated genetic correlations. The UK Biobank dataset was used for the replication studies. We found that rs2961757, located near neuromedin U receptor 2 (NMUR2) on chromosome 5, was genome-wide significant ([Formula: see text] = 0.44, P-value

Indexed as

AsthmaPulmonary Disease, Chronic ObstructiveGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInflammationPolymorphism, Single Nucleotide

Identifiers

PMID36543808
PMCPMC9772307
OpenAlexW4312129673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.