Evidence map›Paper›PMID 36543730›Full record

ArticleInternational dental journal2023

Use of Melatonin/Decorticotomy and Autogenous Bone Graft in Induced 1-Wall Defect.

Hala H Hazzaa, Mai S Attia, Marwa A M El Shiekh, Mohammed E Grawish, Mohamed Moawed I Ghoneim, Nahed M Adly, Noha S Shams, Mohamed A El-Mahdy, Gasser M Elewa

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Article in International dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hala H HazzaaProfessor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt; Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Dakahlia, Egypt. Electronic address: hala.hazzaa@yahoo.com.
Mai S AttiaProfessor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Dakahlia, Egypt; Professor of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Oral and Dental Medicine, Misr International University, Cairo, Egypt.
Marwa A M El ShiekhAssociate Professor of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Mohammed E GrawishProfessor of Oral Biology, Faculty of Dentistry, Mansoura University, Egypt; Professor of Oral Biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Dakahlia, Egypt.
Mohamed Moawed I GhoneimAssociate Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sinai University, Egypt.
Nahed M AdlyAssociate Professor of Oral and Maxillofacial Surgery, Faculty of Dental Medicine Al-Azhar University, Cairo, Egypt, Faculty of Dentistry, Al Nahda University, Benisuef, Egypt.
Noha S ShamsLecturer of Oral pathology, Faculty of Oral and dental Medicine, Ahram Canadian University, 6th of October, Egypt.
Mohamed A El-MahdyLecturer of Oral and Maxillofacial Surgery, Faculty of Dentistry , Al Nahda University, Benisuef, Egypt.
Gasser M ElewaLecturer of Laser Applications in Dentistry, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Dakahlia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was designed to investigate the effect of intramarrow penetration (IMP) and 1% melatonin (MLN) gel on the remodelling process of autogenous bone graft (ABG) in an induced 1-osseous wall defect model.

methodsSixty-four intrabony induced mandibular defects were created on the distal side of premolars-P1, P2, P3, and P4 (on each side)-in 8 beagle dogs. A ligature-induced periodontitis was initiated in each defect. Defects were then divided into 4 equal groups. Group I was treated with open-flap debridement (OFD) alone, group II was treated with OFD/ABG, group III was treated with OFD/IMP/ABG, and group IV was treated with OFD/ABG/IMP/1% MLN gel. The study parameters were bone fill, histologic analysis, and immunohistochemical evaluation of endothelial nitric oxide synthase (eNOS) expression at 2-week (2W) and 8-week (8W) time intervals.

resultsAt 8W, significant differences were revealed amongst all groups regarding the amount of bone fill and eNOS expressions (P < .001). Bone fill percentages were 55.5%, 22.3%, 16.8%, and 0% in groups IV, III, II, and I, respectively. eNOS expressions were 1.68 ± 0.06, 8.43 ± 0.04, 16.80 ± 0.17, and 1.97 ± 0.07 in groups IV, III, II, and I, respectively. The favourable results were in line with group IV.

conclusionsAccording to these preliminary results, defects treated by ABG augmented with IMP and 1% MLN gel revealed a greater amount of bone fill and reduced eNOS expression. This combination is therefore highly suggested as an adjunct to ABG.

Indexed as

Alveolar Bone LossMelatoninAnimalsDogsGuided Tissue Regeneration, PeriodontalHumansTreatment OutcomeMelatoninAutogenous bone graftIntrabony defectIntramarrow penetrationMelatonin

Identifiers

PMID36543730
PMCPMC10350604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.