Evidence map›Paper›PMID 36543610›Full record

ReviewTrends in cognitive sciences2023

Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation.

Miles Wischnewski, Ivan Alekseichuk, Alexander Opitz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cognitive sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  4. Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miles WischnewskiDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Ivan AlekseichukDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. Electronic address: ialeksei@umn.edu.
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. Electronic address: aopitz@umn.edu.

Funding

Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain NetworksRF1MH124909 · NIMH · UNIVERSITY OF MINNESOTA · PI OPITZ, ALEXANDER · 2020 to 2020
$2.4M
Personalized Closed-loop Theta Burst Stimulation for Treatment of DepressionK99MH128454 · NIMH · UNIVERSITY OF MINNESOTA · PI ALEKSEICHUK, IVAN · 2022 to 2023
$212k
NIMH NIH HHS K99 MH128454NIMH NIH HHS RF1 MH124909
6 · The paper itself

Abstract

Transcranial alternating current stimulation (tACS) can modulate human neural activity and behavior. Accordingly, tACS has vast potential for cognitive research and brain disorder therapies. The stimulation generates oscillating electric fields in the brain that can bias neural spike timing, causing changes in local neural oscillatory power and cross-frequency and cross-area coherence. tACS affects cognitive performance by modulating underlying single or nested brain rhythms, local or distal synchronization, and metabolic activity. Clinically, stimulation tailored to abnormal neural oscillations shows promising results in alleviating psychiatric and neurological symptoms. We summarize the findings of tACS mechanisms, its use for cognitive applications, and novel developments for personalized stimulation.

Indexed as

Transcranial Direct Current StimulationBrainHumanscognitive performanceneural oscillationsneuromodulationnon-invasive brain stimulationtranscranial alternating current stimulationtranscranial brain stimulation

Identifiers

PMID36543610
PMCPMC9852081

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.