ArticleNeurology2023
Sex Differences in Clinical Features, Treatment, and Lifestyle Factors in Patients With Cluster Headache.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.The journal of headache and pain · 2026Pooled it
- Investigating Vitamin D Receptor Genetic Markers in a Cluster Headache Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- The Prevalence and Incidence of Cluster Headache: A Norwegian Population-Based Time-Trend Study.Neurology · 2026Article
- Abnormal imaging features of episodic cluster headache and episodic migraine: a multimodal 7T MRI study.The journal of headache and pain · 2026Article
- Sex differences in cluster headache: insights from the Chinese Cluster Headache Register Individual Study (CHRIS).The journal of headache and pain · 2026Observational
- Smoking and cluster headache: clinical, gender, and treatment insights from a cross-sectional cluster analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Risk and reward seeking behaviour in episodic cluster headache - a psychometric and behavioural study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Integrative Migraine Therapy: From Current Concepts to Future Directions-A Plastic Surgeon's Perspective.Medicina (Kaunas, Lithuania) · 2025Review
- Hallmarks of primary headache: part 3 - cluster headache.The journal of headache and pain · 2025Review
- Article
- Reviewing the complex relationship between circadian rhythms and cluster headache.Cephalalgia : an international journal of headache · 2025Review
- Exploration of Prolonged Remission and the Natural Course of Cluster Headache: An Interview-Based Cohort Study.Neurology · 2025Article
- Trigemino-autonomic activation in a human trigeminal pain model.BMC neurology · 2025Article
- Headache Phenotype and the Psychosocial Burden of Cluster Headaches: An Analysis of Patients Prior to Hospitalization.Pain and therapy · 2025Article
- Gender-specific inflammatory burden and headache risk in youth: a NHANES analysis.Head & face medicine · 2024Article
- The Prevalence and Clinical Phenotypes of Cluster Headache in Relation with Latitude.Current pain and headache reports · 2024Review
- Genetic and Phenotypic Profiling of Triptan Users in a Swedish Cluster Headache Cohort.Journal of molecular neuroscience : MN · 2024Article
- Cluster headache: an update on clinical features, epidemiology, pathophysiology, diagnosis, and treatment.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCluster headache is considered a male-dominated disorder, but we have previously suggested that female patients may display a more severe phenotype. Studies on sex differences in cluster headache have been conflicting; therefore, this study, with the largest validated cluster headache material at present, gives more insights into sex-specific characteristics of the disease. The objective of this study was to describe sex differences in patient demographics, clinical phenotype, chronobiology, triggers, treatment, and lifestyle in a Swedish cluster headache population.
methodsStudy participants were identified by screening medical records from 2014 to 2020, requested from hospitals and neurology clinics in Sweden for the
resultsA total of 874 study participants with a verified cluster headache diagnosis were included. Of the participants, 575 (66%) were male and 299 (34%) were female, and biological sex matched self-reported sex for all. Female participants were to a greater extent diagnosed with the chronic cluster headache subtype compared with male participants (18% vs 9%, DISCUSSION: With this in-depth analysis of a well-characterized cluster headache population, we could demonstrate that there are significant differences between male and female participants with cluster headache, which should be regarded at the time of diagnosis and when choosing treatment options. The data suggest that female patients generally may be more gravely affected by cluster headache than male patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.