Evidence map›Paper›PMID 36543503›Full record

ArticleJACC. Clinical electrophysiology2022

Serial 7-Day Electrocardiogram Patch Screening for AF in High-Risk Older Women by the CHARGE-AF Score.

Jeffrey Y Lin, Joseph Larson, Jenny Schoenberg, Alejandra Sepulveda, Lesley Tinker, Matthew Wheeler, Christine Albert, JoAnn E Manson, Gretchen Wells, Lisa W Martin and 7 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Clinical electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05366803 (Women's Health Initiative Strong and Healthy Silent Atrial Fibrillation Recording Study), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05366803 nacompletednot on this map

Women's Health Initiative Strong and Healthy Silent Atrial Fibrillation Recording Study

TypeinterventionalSponsorStanford UniversityRan2017 to 2020Enrolled1,257ConditionsAtrial FibrillationArmsPhysical Activity
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Jeffrey Y LinDepartment of Medicine, Stanford University, Stanford, California, USA.
Joseph LarsonFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Jenny SchoenbergFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Alejandra SepulvedaDepartment of Medicine, Stanford University, Stanford, California, USA.
Lesley TinkerFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Matthew WheelerDepartment of Medicine, Stanford University, Stanford, California, USA.
Christine AlbertDepartment of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
JoAnn E MansonBrigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Gretchen WellsDepartment of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Lisa W MartinDepartment of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Victor FroelicherDepartment of Medicine, Stanford University, Stanford, California, USA.
Mike LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York, USA.
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Mark A HlatkyDepartment of Medicine, Stanford University, Stanford, California, USA.
Philip GreenlandDepartment of Medicine, Northwestern University, Evanston, Illinois, USA.
Marcia L StefanickDepartment of Medicine, Stanford University, Stanford, California, USA.
Marco V PerezDepartment of Medicine, Stanford University, Stanford, California, USA. Electronic address: mvperez@stanford.edu.
Stanford University · USFred Hutch Cancer Center · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USGeorge Washington University · USNorthwestern University · USUniversity at Buffalo, State University of New York · USUniversity of Kentucky · US

Funding

WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2M
The WHI Strong and Healthy SilenT Atrial fibrillation Recording study (WHISH STAR)R01HL136390 · NHLBI · STANFORD UNIVERSITY · PI PEREZ, MARCO V · 2017 to 2021
$3.6M
NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS R01 HL136390WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

backgroundAsymptomatic atrial fibrillation (AF) is associated with an increased risk of stroke. The yield of serial electrocardiographic (ECG) screening for AF is unknown.

objectivesThe aim of this study was to determine the frequency of AF detected by serial, 7-day ECG patch screenings in older women identified as having an elevated risk of AF according to the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology)-AF clinical prediction score.

methodsPostmenopausal women with a 5-year predicted risk of new-onset AF ≥5% according to CHARGE-AF were recruited from the ongoing WHISH (Women's Health Initiative Strong and Healthy) randomized trial of a physical activity intervention. Participants with AF at baseline by self-report or medical records review were excluded. Screening with 7-day ECG patch monitors was performed at baseline, 6 months, and 12 months from study enrollment.

resultsOn baseline monitoring, 2.5% of the cohort had AF detected, increasing to 3.7% by 6 months and 4.9% cumulatively by 12 months. Yield of patch screening was higher among participants with a higher (≥10%) CHARGE-AF score: 4.2% had AF detected at baseline, 5.9% at 6 months, and 7.2% at 12 months. Most participants with patch-identified AF never had a clinical diagnosis of AF (36 of 46 [78%]).

conclusionsOlder women with an elevated CHARGE-AF score had a high prevalence of AF on 7-day ECG patch screening. Serial screening over 12 months substantially increased the detection of AF. These data can be useful in helping identify high-risk participants for enrollment in future studies of the management of asymptomatic AF.(Women's Health Initiative Silent Atrial Fibrillation Recording Study [WHISH STAR]; NCT05366803.).

Indexed as

Atrial FibrillationStrokeAgedElectrocardiographyFemaleHeartHumansMass Screeningarrhythmiasatrial fibrillationscreeningWomen’s Health Initiative

Identifiers

PMID36543503
PMCPMC9986967
OpenAlexW4307569457

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.