Evidence map›Paper›PMID 36543322›Full record

ArticleNature2023

Reconstituting human somitogenesis in vitro.

Yoshihiro Yamanaka, Sofiane Hamidi, Kumiko Yoshioka-Kobayashi, Sirajam Munira, Kazunori Sunadome, Yi Zhang, Yuzuru Kurokawa, Rolf Ericsson, Ai Mieda, Jamie L Thompson and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 118 citations in OpenAlex.

  1. Review
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  8. Review
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  10. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
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  18. Review
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  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Yoshihiro Yamanaka *Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Sofiane Hamidi *Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Kumiko Yoshioka-KobayashiInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Sirajam MuniraInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Kazunori SunadomeInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Yi ZhangInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Yuzuru KurokawaInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Rolf EricssonInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Ai MiedaInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Jamie L ThompsonThe Francis Crick Institute, London, UK.
Janet KerwinHDBR, Newcastle University, Newcastle Upon Tyne, UK.
Steven LisgoHDBR, Newcastle University, Newcastle Upon Tyne, UK.
Takuya YamamotoInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.ORCID 0000-0002-0022-3947
Naomi MorisThe Francis Crick Institute, London, UK.ORCID 0000-0003-1910-5454
Alfonso Martinez-AriasDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra and ICREA, Barcelona, Spain.
Taro TsujimuraInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.
Cantas AlevInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan. alev.cantas.8m@kyoto-u.ac.jp.ORCID 0000-0002-4879-8782
Kyoto University · JPNewcastle University · GBThe Francis Crick Institute · GBInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Medical Research Council MR/R006237/1Medical Research Council MR/V005367/1Medical Research Council MR/V005367/2
6 · The paper itself

Abstract

The segmented body plan of vertebrates is established during somitogenesis, a well-studied process in model organisms; however, the details of this process in humans remain largely unknown owing to ethical and technical limitations. Despite recent advances with pluripotent stem cell-based approaches

Indexed as

Body PatterningCell Culture Techniques, Three DimensionalSomitesBasic Helix-Loop-Helix ProteinsExtracellular MatrixFibroblast Growth FactorsHumansInduced Pluripotent Stem CellsIn Vitro TechniquesModels, BiologicalMutationSpinal DiseasesTretinoinWnt Signaling PathwayBasic Helix-Loop-Helix ProteinsFibroblast Growth FactorsHES7 protein, humanMESP2 protein, humanTretinoin

Identifiers

PMID36543322
OpenAlexW4312095185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.