Evidence map›Paper›PMID 36543321›Full record

ArticleNature2023

Reconstruction and deconstruction of human somitogenesis in vitro.

Yuchuan Miao, Yannis Djeffal, Alessandro De Simone, Kongju Zhu, Jong Gwan Lee, Ziqi Lu, Andrew Silberfeld, Jyoti Rao, Oscar A Tarazona, Alessandro Mongera and 5 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 114 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. New developments and applications of human organoids.Nature reviews. Molecular cell biology · 2026
    Review
  7. Article
  8. Article
  9. Review
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  11. Article
  12. Review
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  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Yuchuan MiaoDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0600-6609
Yannis Djeffal *Department of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8551-4793
Alessandro De Simone *Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
Kongju ZhuDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9720-8128
Jong Gwan LeeDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Ziqi LuDepartment of Cell Biology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6290-0819
Andrew SilberfeldDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2308-4994
Jyoti RaoDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Oscar A TarazonaDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Alessandro MongeraDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Pietro RigoniDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Margarete Diaz-CuadrosDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Laura Min Sook SongDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Stefano Di TaliaDepartment of Cell Biology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-9758-7925
Olivier PourquiéDepartment of Genetics, Harvard Medical School, Boston, MA, USA. pourquie@genetics.med.harvard.edu.ORCID 0000-0001-5189-1227
Brigham and Women's Hospital · USDuke Medical Center · US

Funding

Role of Energy Metabolism in Patterning the Vertebrate Musculo-Skeletal AxisR01HD085121 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI OLIVIER POURQUIE · 2016 to 2026
$6.8M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8M
TissueCyte 1600FC Whole Mount Tissue ScannerS10OD026866 · OD · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2019
$612k
NICHD NIH HHS R01 HD085121NIH HHS S10 OD026866NINDS NIH HHS P30 NS072030
6 · The paper itself

Abstract

The vertebrate body displays a segmental organization that is most conspicuous in the periodic organization of the vertebral column and peripheral nerves. This metameric organization is first implemented when somites, which contain the precursors of skeletal muscles and vertebrae, are rhythmically generated from the presomitic mesoderm. Somites then become subdivided into anterior and posterior compartments that are essential for vertebral formation and segmental patterning of the peripheral nervous system

Indexed as

Body PatterningCell Culture Techniques, Three DimensionalSomitesBasic Helix-Loop-Helix ProteinsBiological ClocksEpitheliumHumansIn Vitro TechniquesSpineBasic Helix-Loop-Helix ProteinsMESP2 protein, human

Identifiers

PMID36543321
PMCPMC10018515
OpenAlexW4312095214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.