Evidence map›Paper›PMID 36542812›Full record

ArticleThe journal of physical chemistry. B2023

Electrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48.

Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Eli Hvastkovs, Jun-Yong Choe, Judy E Kim, Adam R Offenbacher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kristin TysonDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.
Chanin B TangtartharakulDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, United States.
Matthias ZeugDepartment of Chemistry, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville North Carolina, 27858, United States.
Nathan FindlingDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.
Alice HaddyDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Eli HvastkovsDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.ORCID 0000-0002-7957-9718
Jun-Yong ChoeDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.
Judy E KimDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-8695-4363
Adam R OffenbacherDepartment of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.ORCID 0000-0001-6990-7178
East Carolina University · USUniversity of California San Diego · USUniversity of North Carolina at Greensboro · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptophan serves as an important redox-active amino acid in mediating electron transfer and mitigating oxidative damage in proteins. We previously showed a difference in electrochemical potentials for two tryptophan residues in azurin with distinct hydrogen-bonding environments. Here, we test whether reducing the side chain bulk at position Phe110 to Leu, Ser, or Ala impacts the electrochemical potentials (

Indexed as

AzurinHydrogenOxidation-ReductionTryptophanWaterAzurinHydrogenTryptophanWater

Identifiers

PMID36542812
PMCPMC9841983
OpenAlexW4312062843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.