Observational studyCancer control : journal of the Moffitt Cancer Center
Quality Assessment of Cervical Cytology Practices in Estonia From 2007 to 2018.
Observational study in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Nationwide Study on the Cervical Cancer Screening Pathway in Estonia.International journal of cancer · 2026Article
- Changing burden of cancers related to human papillomavirus in Estonia: a population-based registry study.Acta oncologica (Stockholm, Sweden) · 2026Article
- Educational inequalities in cervical cancer mortality in the Baltic countries and Finland in the context of organized screening: A register-based study 2000-2015.International journal of cancer · 2026Article
- Regional mortality disparities in Central and Eastern Europe 2000-22.Journal of public health (Oxford, England) · 2026Article
- In situ phenotypic and karyotypic co-detection of aneuploid TCs and TECs in cytological specimens with abnormal cervical screening results.BMC cancer · 2025Article
- Development of a clinical prediction model for pathological upgrading in low-grade squamous intraepithelial lesions following cervical conization.CytoJournal · 2024Article
- Assessing the Quality of the Endocervical Component: Pitfalls to Cervical Cancer Screening in Limpopo Province, South Africa.Cancer control : journal of the Moffitt Cancer CenterArticle
- Prevalence of Human Papillomavirus Subtypes and Related Cytology in Estonian Cervical Cancer Screening Population in 2021.Cancer control : journal of the Moffitt Cancer CenterArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervical cancer incidence and mortality in Estonia are among the highest in Europe, although the overall coverage with cervical cytology is high. This indicates potential issues with the quality of collection and/or laboratory evaluation of cervical cytology.
objectivesThe aim of the retrospective observational study was to assess the quality of cervical cytology specimen collection, evaluation, and reporting using laboratory reports in Estonia.
methodsThe study included women with a cervical cancer diagnosis in 2017-2018. Cervical cytology and histology reports for these women in 2007-2018 were obtained from ten laboratories. We described the quality of cytology specimen collection and reporting of cytology results. Multivariate logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) to identify factors associated with NILM as the last cervical cytology result within 5 or 2 years before the cervical cancer diagnosis. Also, we calculated cytology-histology correlation (CHC).
resultsWe identified 503 cytology and 100 histology reports from 138 women. The laboratories differed greatly regarding human resources, work capacity and volume. Differences between local and regional laboratories were observed in reporting specimen adequacy (P < .001). We found that local laboratories had 3 times higher odds (OR = 2.95, 95% CI: 1.05-8.33) of reporting normal results 2 years before cancer diagnosis than regional laboratories. According to the CHC, 58.9% of pairs were in agreement.
conclusionsThe study showed considerable heterogeneity and suboptimal performance of cervical cytology practices in Estonia, particularly at local laboratories. Efforts to improve laboratory quality assurance are crucial.
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