ArticleScience advances2022
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Who cites it
25 citing papers in PubMed, 26 citations in OpenAlex.
- A collagen orientation switch reshapes fin architecture.iScience · 2026Article
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- Roles of integrin β1 and discoidin domain receptor 2 in cranial regeneration and skeletal progenitor cell function.International journal of oral science · 2026Article
- Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies.Journal of orthopaedic translation · 2026Review
- Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.Journal of dental research · 2026Article
- Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.Bone research · 2026Article
- When Bone Forms Where It Shouldn't: Heterotopic Ossification in Muscle Injury and Disease.International journal of molecular sciences · 2025Review
- Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification.Bone research · 2025Article
- Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation.Bone research · 2025Article
- Ultrasound-generated bubbles enhance osteogenic differentiation of mesenchymal stromal cells in composite collagen hydrogels.Bioactive materials · 2025Article
- Review
- A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury.Cell reports. Medicine · 2024Article
- Endothelial BMAL1 decline during aging leads to bone loss by destabilizing extracellular fibrillin-1.The Journal of clinical investigation · 2024Article
- Oncogenic mechanisms of COL10A1 in cancer and clinical challenges (Review).Oncology reports · 2024Review
- Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis.Cell discovery · 2024Review
- Preliminary study of the homeostatic regulation of osseointegration by nanotube topology.Materials today. Bio · 2024Article
- The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair.Bone research · 2024Article
- PpSCARECROW1 (PpSCR1) regulates leaf blade and mid-vein development in Physcomitrium patens.Plant molecular biology · 2024Article
- DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression.Oncogene · 2024Article
- Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification.Biochemical and biophysical research communications · 2023Article
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Authors and funding
20 authors at 4 institutions in 1 country.
Chase A PaganiCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0001-9834-2516
Alec C BancroftCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0001-9505-4762
Robert J TowerCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0001-5856-5758
Nicholas LivingstonCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.
Yuxiao SunCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0002-8472-2582
Jonathan Y HongCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0002-0241-2434
Robert N KentBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1287-6301
Amy L StrongSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2581-2481
Johanna H NunezCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.
Jessica Marie R MedranoCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0002-1109-6904
Nicole PatelSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2967-4167
Benjamin A NanesDepartment of Dermatology, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0001-9686-1611
Kevin M DeanLydia Hill Department of Bioinformatics, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0003-0839-2320
Zhao LiDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9276-9129
Chunxi GeSchool of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7719-1077
Brendon M BakerBiomedical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-2785-1070
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-2002-622X
Stephen J WeissLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1864-6075
Renny T FranceschiSchool of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1405-2541
Benjamin LeviCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0001-8272-7139
Organogenesis (United States) · USUniversity of Michigan · USJohns Hopkins University · USThe University of Texas Southwestern Medical Center · US
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3MTissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3MTechnical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ LevelU54CA268072 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SEAN J MORRISON · 2021 to 2026
$9.1MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MUTSW-UNC Center for Cell Signaling AnalysisRM1GM145399 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Kevin Michael Dean, Klaus M. Hahn · 2022 to 2026
$6.2MUniversity of Michigan Surgical Oncology Research Training ProgramT32CA009672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, WEIPING ZOU · 1991 to 2026
$6.0MPrune Belly Syndrome: Mechanisms of Filamin A MutationsR01DK127589 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAKER, LINDA A., QIN, JUN · 2020 to 2024
$2.5MImpacts of mechanosensation and matrix architecture on cell fate specification in traumatic heterotopic ossification - diversity supplementR01AR078324 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2021 to 2025
$2.4MDiscoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4MDermatology Research Training ProgramT32AR065969 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI PONCIANO D CRUZ, Tamia Alisha Harris-Tryon · 2014 to 2026
$1.6MTargeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5MNCI NIH HHS P30 CA142543NCI NIH HHS T32 CA009672NCI NIH HHS U54 CA268072NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR071379NIAMS NIH HHS R01AR071379NIAMS NIH HHS R01 AR078324NIAMS NIH HHS T32 AR065969NICHD NIH HHS R21 HD105189NIDCR NIH HHS R01 DE029465NIDCR NIH HHS R21 DE029012NIDCR NIH HHS T32 DE007057NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK127589NIGMS NIH HHS R01 GM123069NIGMS NIH HHS RM1 GM145399
Abstract
Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell differentiation, forming bone within soft tissues of the musculoskeletal system following traumatic injury. Recent work has shown that HO is influenced by ECM-MLin cell receptor signaling, but how ECM binding affects cellular outcomes remains unclear. Using time course transcriptomic and proteomic analyses, we identified discoidin domain receptor 2 (DDR2), a cell surface receptor for fibrillar collagen, as a key MLin cell regulator in HO formation. Inhibition of DDR2 signaling, through either constitutive or conditional
Indexed as
Discoidin Domain Receptor 2AnimalsCell DifferentiationExtracellular MatrixMiceProteomicsSignal TransductionDiscoidin Domain Receptor 2
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