Evidence map›Paper›PMID 36542545›Full record

ArticleBiomacromolecules2023

A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D Bioprinting.

Alessandro Zaupa, Claudia Terraza, Phammela N Abarzúa-Illanes, Nicholas Byres, Gabriela Zavala, Jimena Cuenca, Carmen Hidalgo, Sergio M Viafara-Garcia, Bettina Wolf, Karina Pino-Lagos and 5 more

Open access · greenAbstract read
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Alessandro ZaupaLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Claudia TerrazaLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Phammela N Abarzúa-IllanesLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Nicholas ByresLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Gabriela ZavalaLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Jimena CuencaLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Carmen HidalgoLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Sergio M Viafara-GarciaLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Bettina WolfSchool of Biosciences, The University of Nottingham, Sutton Bonington Campus, Loughborough LE12 5RD, United Kingdom.
Karina Pino-LagosCentro de Investigación Biomédica e Innovación, Facultad de Medicina, Universidad de los Andes, Santiago 7620001, Chile.
Jonny J BlakerBio-Active Materials Group, Department of Materials, MSS Tower, The University of Manchester, Manchester M13 9PL, United Kingdom.ORCID 0000-0003-1112-8619
Mayan RumbakStratasys Ltd., 1 Holtzman Street, Tamar Science Park, Rehovot 7612401, Israel.
Maroun KhouryLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Javier EnrioneBiopolymer Research and Engineering Lab (BiopREL), School of Nutrition and Dietetics, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.
Juan Pablo AcevedoLaboratory of Nano-Regenerative Medicine, Centro de Investigación Biomédica e Innovación, Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile.ORCID 0000-0002-7404-3762
Universidad de Los Andes, Chile · CLStratasys (Israel) · ILUniversity of Manchester · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing demand for tissue replacement has encouraged scientists worldwide to focus on developing new biofabrication technologies. Multimaterials/cells printed with stringent resolutions are necessary to address the high complexity of tissues. Advanced inkjet 3D printing can use multimaterials and attain high resolution and complexity of printed structures. However, a decisive yet limiting aspect of translational 3D bioprinting is selecting the befitting material to be used as bioink; there is a complete lack of cytoactive bioinks with adequate rheological, mechanical, and reactive properties. This work strives to achieve the right balance between resolution and cell support through methacrylamide functionalization of a psychrophilic gelatin and new fluorosurfactants used to engineer a photo-cross-linkable and immunoevasive bioink. The syntonized parameters following optimal formulation conditions allow proficient printability in a PolyJet 3D printer comparable in resolution to a commercial synthetic ink (∼150 μm). The bioink formulation achieved the desired viability (∼80%) and proliferation of co-printed cells while demonstrating

Indexed as

BioprintingGelatinPrinting, Three-DimensionalRheologyTissue EngineeringTissue ScaffoldsGelatin

Identifiers

PMID36542545
PMCPMC9833123
OpenAlexW4312065896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.