Evidence map›Paper›PMID 36542294›Full record

ReviewCurrent osteoporosis reports2023

Energy Balance and Bone Health: a Nutrient Availability Perspective.

Beatriz Bermudez, Toru Ishii, Yuan-Haw Wu, R Dana Carpenter, Vanessa D Sherk

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  2. Article
  3. Review
  4. The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Beatriz BermudezDepartment of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA.
Toru IshiiDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yuan-Haw WuDepartment of Surgery, Johns Hopkins University, Baltimore, MD, USA.
R Dana CarpenterDepartment of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA.
Vanessa D SherkDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. vanessa.sherk@nih.gov.ORCID 0000-0001-6388-8201
University of Colorado Anschutz Medical Campus · USCenter for Scientific Review · USJohns Hopkins University · USUniversity of Colorado Denver · US

Funding

Institutional Career Development CoreKL2TR002534 · NCATS · UNIVERSITY OF COLORADO DENVER · PI BURNHAM, ELLEN L · 2018 to 2022
$4.6M
NCATS NIH HHS KL2 TR002534
6 · The paper itself

Abstract

purpose of reviewObesity is highly prevalent and is associated with bone fragility and fracture. The changing nutrient availability to bone in obesity is an important facet of bone health. The goal of this article is to summarize current knowledge on the effects of carbohydrate and dietary fat availability on bone, particularly in the context of other tissues. RECENT

findingsThe skeleton is a primary site for fatty acid and glucose uptake. The trafficking of carbohydrates and fats into tissues changes with weight loss and periods of weight gain. Exercise acutely influences nutrient uptake into bone and may affect nutrient partitioning to bone. Bone cells secrete hormones that signal to the brain and other tissues information about its energetic state, which may alter whole-body nutrient trafficking. There is a critical need for studies to address the changes that metabolic perturbations have on nutrient availability in bone.

Indexed as

Bone DensityObesityDietary FatsEnergy IntakeEnergy MetabolismHumansNutrientsDietary FatsNutrientsBone marrow adiposityBone remodelingEnergy balanceHigh-fat dietNutrient traffickingWeight cycling

Identifiers

PMID36542294
OpenAlexW4312070513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.