Evidence map›Paper›PMID 36542159›Full record

ArticleJournal of cancer research and clinical oncology2023

Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.

Nikola Zmarzły, Szymon Januszyk, Paweł Mieszczański, Emilia Morawiec, Paulina Buda, Konrad Dziobek, Marcin Opławski, Dariusz Boroń

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nikola ZmarzłyDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland. nikola.zmarzly@gmail.com.
Szymon JanuszykICZ Healthcare Hospital in Zywiec, Zywiec, Poland.
Paweł MieszczańskiHospital of Ministry of Interior and Administration, Katowice, Poland.
Emilia MorawiecDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland.
Paulina BudaDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland.
Konrad DziobekDepartment of Gynecology and Obstetrics With Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Krakow, Poland.
Marcin OpławskiDepartment of Gynecology and Obstetrics With Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Krakow, Poland.
Dariusz BorońDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland.
University of Silesia in Katowice · PLAndrzej Frycz Modrzewski Krakow University · PLMinistry of Interior and Administration · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChanges in the activity of endothelins and their receptors may promote neoplastic processes. They can be caused by epigenetic modifications and modulators, but little is known about endothelin-3 (EDN3), particularly in endometrial cancer. The aim of the study was to determine the expression profile of endothelin family and their interactions with miRNAs, and to assess the degree of EDN3 methylation.

methodsThe study enrolled 45 patients with endometrioid endometrial cancer and 30 patients without neoplastic changes. The expression profile of endothelins and their receptors was determined with mRNA microarrays and RT-qPCR. The miRNA prediction was based on the miRNA microarray experiment and the mirDB tool. The degree of EDN3 methylation was assessed by MSP.

resultsEDN1 and EDNRA were overexpressed regardless of endometrial cancer grade, which may be due to the lack of regulatory effect of miR-130a-3p and miR-485-3p, respectively. In addition, EDN3 and EDNRB were significantly downregulated.

conclusionThe endothelial axis is disturbed in endometrioid endometrial cancer. The observed silencing of EDN3 activity may be mainly due to DNA methylation.

Indexed as

Carcinoma, EndometrioidEndometrial NeoplasmsMicroRNAsEndothelin-1Endothelin-3EndothelinsFemaleGene Expression Regulation, NeoplasticHumansReceptor, Endothelin AEndothelin-1Endothelin-3EndothelinsMicroRNAsMIRN485 microRNA, humanReceptor, Endothelin ADNA methylationEDN3Endometrial cancerEndothelinsmiRNA

Identifiers

PMID36542159
PMCPMC10356642
OpenAlexW4312067408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.