ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2023
Menopause-Related Changes in Body Composition Are Associated With Subsequent Bone Mineral Density and Fractures: Study of Women's Health Across the Nation.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Examining the relationship between D3Cr muscle mass, physical performance, and functional limitation in postmenopausal women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- An index of net bone formation relative to resorption is associated with incident fracture during the menopause transition and postmenopause.JBMR plus · 2026Article
- Global burden of fall-related injuries attributable to low bone mineral density in women aged 50-69 years: inequalities, projections to 2050, and Mendelian randomisation.Journal of global health · 2026Article
- Associations between body composition and bone loss in early postmenopausal women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Advanced Biomaterial-Based In Vitro Osteoarthritis Models: Integrating Sex as a Biological Variable in Hormonal, Subchondral Bone, and Mechanobiological Pathways.Journal of functional biomaterials · 2026Review
- Adipose-muscle crosstalk during the menopausal transition: mechanistic links to sarcopenic obesity in midlife women.Frontiers in endocrinology · 2026Review
- Interplay of menopause, coronary artery calcium score and cardiovascular disease risk.World journal of cardiology · 2025Article
- Article
- Estimating Net Bone Formation Relative to Resorption Using Reference Bone Turnover Markers.The Journal of clinical endocrinology and metabolism · 2025Article
- Interpretable Machine Learning for Osteopenia Detection: A Proof-of-Concept Study Using Bioelectrical Impedance in Perimenopausal Women.Journal of functional morphology and kinesiology · 2025Article
- The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007-2016.Food science & nutrition · 2025Article
- Exploring the association between bioelectrical impedance parameters and body composition in women with and without dysmenorrhea and postmenopause.Physiological reports · 2025Article
- The association between visceral fat metabolic score and stroke: mediation by declining kidney function.Diabetology & metabolic syndrome · 2025Article
- Vitamin K and women's health: a review.Frontiers in global women's health · 2025Review
- Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population.BMJ open ophthalmology · 2024Article
- Joint association of weight-adjusted-waist index and physical activity with insulin resistance in adolescents: a cross-sectional study.BMC endocrine disorders · 2024Article
- Association of weight-adjusted waist index with all-cause mortality among non-Asian individuals: a national population-based cohort study.Nutrition journal · 2024Article
- Association of weight-adjusted waist index with all-cause and cause-specific mortality among cancer survivors: a cohort study of the NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Relationships between longitudinal changes in body composition and bone mineral density in middle-to-older aged Australians.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Association between the weight-adjusted waist index and stroke: a cross-sectional study.BMC public health · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During the menopause transition (MT), lean mass decreases and fat mass increases. We examined the associations of these body composition changes during the MT (2 years before to 2 years after the final menstrual period) with bone mineral density (BMD) at the end of the MT and fracture after the MT. We included 539 participants from the Study of Women's Health Across the Nation who were not taking bone-beneficial or bone-detrimental medications before or during the MT. Using multivariable linear regression, we assessed the independent associations of % lean mass loss and % fat mass gain during the MT (mutually adjusted) with femoral neck (FN) and lumbar spine (LS) BMD at the end of the MT, adjusted for pre-MT BMD, pre-MT lean and fat mass, race/ethnicity, Study of Women's Health Across the Nation (SWAN) study site, age, and cigarette use. We used Cox proportional hazards regression to quantify the relations of % lean loss and % fat gain during the MT with fracture after the MT. The Cox model was adjusted for the covariates above plus post-MT use of bone-detrimental medications, and censored at the first use of bone-beneficial medications; we further controlled for FN or LS BMD at the end of the MT. Adjusted for covariates, each standard deviation (SD) (6.9%) increment in lean mass loss was associated with 0.010 g/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.