Evidence map›Paper›PMID 36542059›Full record

ArticleJournal of the American Chemical Society2023

Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer.

Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Stereoselective Synthesis of Aminals Through Enzyme-Catalyzed Intermolecular C(spAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Desymmetrization ofJournal of the American Chemical Society · 2026
    Article
  5. Direct enantioselective C(spNature chemistry · 2026
    Article
  6. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  7. Review
  8. Photobiocatalytic Enantioselective Benzylic C(spJournal of the American Chemical Society · 2025
    Article
  9. ACS catalysis · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xinkun RenDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.ORCID 0000-0001-6645-9074
Bo M CoutureDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.ORCID 0000-0001-6722-0604
Ningyu LiuDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.
Manjinder S LallPfizer Inc., Medicine and Design, Groton, Connecticut 06340, United States.ORCID 0000-0002-2882-8075
Jeffrey T KohrtPfizer Inc., Medicine and Design, Groton, Connecticut 06340, United States.
Rudi FasanDepartment of Chemistry, University of Rochester, Rochester, New York 14627, United States.ORCID 0000-0003-4636-9578
University of Rochester · USPfizer (United States) · US

Funding

Selective P450 Oxidation Catalysts for Synthesis of Bioactive MoleculesR01GM098628 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI FASAN, RUDI · 2012 to 2024
$4.7M
Orbitrap Fusion Lumos Mass Spectrometer for UR Proteomics ResearchS10OD025242 · OD · UNIVERSITY OF ROCHESTER · PI GHAEMMAGHAMI, SINA · 2018 to 2018
$1.1M
NIH Training Grant in Chemistry-Biology InterfaceT32GM145461 · NIGMS · UNIVERSITY OF ROCHESTER · PI KARA L. BREN, Bradley L. Nilsson · 2022 to 2026
$988k
NIH Training Grant in the Chemistry-Biology InterfaceT32GM118283 · NIGMS · UNIVERSITY OF ROCHESTER · PI BREN, KARA L., FASAN, RUDI · 2017 to 2021
$850k
Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF/TOF) Mass SpectrometerS10OD030302 · OD · UNIVERSITY OF ROCHESTER · PI NILSSON, BRADLEY L. · 2021 to 2021
$304k
NIGMS NIH HHS R01 GM098628NIGMS NIH HHS T32 GM118283NIGMS NIH HHS T32 GM145461NIH HHS S10 OD025242NIH HHS S10 OD030302
6 · The paper itself

Abstract

Cyclic amines are ubiquitous structural motifs found in pharmaceuticals and biologically active natural products, making methods for their elaboration via direct C-H functionalization of considerable synthetic value. Herein, we report the development of an iron-based biocatalytic strategy for enantioselective α-C-H functionalization of pyrrolidines and other saturated

Indexed as

AminesBiocatalysisCatalysisMethaneStereoisomerismAminescarbeneMethane

Identifiers

PMID36542059
PMCPMC9837850
OpenAlexW4313455062

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.