Evidence map›Paper›PMID 36542039›Full record

ArticleActa cirurgica brasileira2022

Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation.

Patrícia Lima D'Abadia, Susy Ricardo Lemes, Paulo Roberto de Melo-Reis, Ruy de Souza Lino Júnior, Pablo José Gonçalves, Diego Dos Santos Reis, Graziele Alícia Batista Caixeta, Vanessa Cristine Santana Amaral, Luciane Madureira Almeida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Patrícia Lima D'AbadiaGraduate student. Universidade Estadual de Goiás - Programa Recursos Naturais do Cerrado - Biotechnology Laboratory - Anápolis (GO), Brazil.ORCID http://orcid.org/0000-0003-4756-4869
Susy Ricardo LemesPhD, Assistant professor. Centro Universitário Goyazes - Department of Agricultural Science - Trindade (GO), Brazil.ORCID http://orcid.org/0000-0001-5303-6910
Paulo Roberto de Melo-ReisPhD, Assistant professor. Pontifícia Universidade Católica de Goiás - Biomedicine Department - Laboratory of Experimental and Biotechnological Studies - Goiânia (GO), Brazil.ORCID http://orcid.org/0000-0001-9660-2572
Ruy de Souza Lino JúniorPhD, Associate professor. Universidade Federal de Goiás - Experimental Pathology Laboratory - Institute of Tropical Pathology and Public Health - Goiânia (GO), Brazil.ORCID http://orcid.org/0000-0002-0572-5102
Pablo José GonçalvesPhD, Associate professor. Universidade Federal de Goiás - Institute of Physics - Goiânia (GO), Brazil.ORCID http://orcid.org/0000-0003-0246-1073
Diego Dos Santos ReisGraduate student. Universidade Estadual de Goiás - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.ORCID http://orcid.org/0000-0003-2046-4278
Graziele Alícia Batista CaixetaGraduate student. Universidade Estadual de Goiás - Sciences Applied to Health Products - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.ORCID http://orcid.org/0000-0002-5071-5077
Vanessa Cristine Santana AmaralPhD, Full professor. Universidade Estadual de Goiás - Laboratory of Pharmacology and Toxicology of Natural and Synthetic Products - Anápolis (GO), Brazil.ORCID http://orcid.org/0000-0001-5964-4888
Luciane Madureira AlmeidaPhD, Full professor. Universidade Estadual de Goiás - Biotechnology Laboratory - Anápolis (GO), Brazil.ORCID http://orcid.org/0000-0003-1764-1480
Universidade Estadual de Goiás · BRUniversidade Federal de Goiás · BRCentro Universitário de Goiás · BRPontifícia Universidade Católica de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds.

methodsOne hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen.

resultsThe therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues.

conclusionsH. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.

Indexed as

ApocynaceaeLatexAnimalsCollagenPlant ExtractsRatsSkinWound HealingCollagenLatexPlant Extracts

Identifiers

PMID36542039
PMCPMC9762431
OpenAlexW4312114446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.