Evidence map›Paper›PMID 36541915›Full record

ArticleSpring simulation conference (SpringSim)

A MACHINE LEARNING MODEL TO PREDICT SEIZURE SUSCEPTIBILITY FROM RESTING-STATE FMRI CONNECTIVITY.

Rachael Garner, Marianna La Rocca, Giuseppe Barisano, Arthur W Toga, Dominique Duncan, Paul Vespa

Open access · greenAbstract read
In one paragraph

Article in Spring simulation conference (SpringSim). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
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  9. Review
  10. Default Mode Network Resting State Connectivity Derived From Task-Based fMRI: A Validation Study in People With Epilepsy.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rachael GarnerLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue Los Angeles, CA, USA.
Marianna La RoccaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue Los Angeles, CA, USA.
Giuseppe BarisanoLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue Los Angeles, CA, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue Los Angeles, CA, USA.
Dominique DuncanLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, 2025 Zonal Avenue Los Angeles, CA, USA.
Paul VespaDepartment of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Suite 420, Los Angeles, CA, USA.
University of Southern California · USUniversity of California, Los Angeles · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of disability globally. Many patients develop post-traumatic epilepsy, or recurrent seizures following TBI. In recent years, significant efforts have been made to identify biomarkers of epileptogenesis that may assist in preventing seizure occurrence by identifying high-risk patients. We present a novel method of assessing seizure susceptibility using data from 49 patients enrolled in the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We employ a machine learning paradigm that utilizes a Random Forest classifier trained with resting-state functional magnetic resonance imaging (fMRI) data to predict seizure outcomes. Following 100 rounds of stratified cross-validation with 70% of resting state fMRI scans as the training set and 30% as the testing set, our model was found to assess seizure outcome in the testing set with 69% accuracy. To validate the method, we compared our results with classification by Support Vector Machines and Neural Network classifiers.

Indexed as

fMRImachine learningpost-traumatic epilepsyseizure predictiontraumatic brain injury

Identifiers

PMID36541915
PMCPMC9760283
OpenAlexW2952091391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.