ArticleJournal of virology2023
Neural-Cell-Intrinsic NF-κB Signaling Enhances Reovirus Virulence.
Gwen M Taylor, Andrea J Pruijssers, Pamela H Brigleb, Kay L Fiske, Pengcheng Shang, Kelly Urbanek, Judy J Brown, Dhivyaa Rajasundaram, Terence S Dermody
Open access · greenAbstract read
In one paragraphArticle in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 1 country.
Gwen M Taylor *Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Andrea J Pruijssers *Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Pamela H BriglebInstitute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kay L FiskeDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Pengcheng ShangDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kelly UrbanekDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Judy J BrownElizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Dhivyaa RajasundaramDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Terence S DermodyDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1853-8741 University of Pittsburgh · USVanderbilt University · USVanderbilt University Medical Center · US
Funding
TRAINING GRANT IN MECHANISMS OF VASCULAR DISEASET32HL007751 · NHLBI · VANDERBILT UNIVERSITY · PI BOCK, PAUL E · 1994 to 2014
$6.6MImmunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3MMOLECULAR BASIS OF REOVIRUS PATHOGENESISR01AI038296 · NIAID · VANDERBILT UNIVERSITY · PI DERMODY, TERENCE S. · 1996 to 2019
$3.3MRole of pH-regulated Genes of Candida AlbicansR01AI050800 · NIAID · GEORGETOWN UNIVERSITY · PI FONZI, WILLIAM A. · 2001 to 2004
$1.2MViral Triggers of Celiac DiseaseF31DK108562 · NIDDK · VANDERBILT UNIVERSITY · PI BROWN, JUDY · 2015 to 2017
$74kNHLBI NIH HHS T32 HL007751NIAID NIH HHS R01 AI038296NIAID NIH HHS R01 AI050800NIAID NIH HHS T32 AI060525NIDDK NIH HHS F31 DK108562
6 · The paper itselfAbstract
Pathological effects of apoptosis associated with viral infections of the central nervous system are an important cause of morbidity and mortality. Reovirus is a neurotropic virus that causes apoptosis in neurons, leading to lethal encephalitis in newborn mice. Reovirus-induced encephalitis is diminished in mice with germ line ablation of NF-κB subunit p50. It is not known whether the proapoptotic function of NF-κB is mediated by neural-cell-intrinsic (neural-intrinsic) processes, NF-κB-regulated cytokine production by inflammatory cells, or a combination of both. To determine the contribution of cell type-specific NF-κB signaling in reovirus-induced neuronal injury, we established mice that lack NF-κB p65 expression in neural cells using the
Indexed as
Encephalitis, ViralNeuronsReoviridaeReoviridae InfectionsAnimalsApoptosisChemokinesHost Microbial InteractionsMiceNF-kappa BChemokinesNF-kappa BencephalitisneurovirulenceNF-κBp65RelAreovirus
Identifiers
PMID36541803
PMCPMC9888206
OpenAlexW4312045923
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