Evidence map›Paper›PMID 36541799›Full record

ArticleJournal of virology2023

Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection.

Amanda L Gill, William H Hudson, Rajesh M Valanparambil, Eunseon Ahn, Donald J McGuire, Andreas Wieland, Daniel T McManus, Haydn T Kissick, Rama S Akondy, Rafi Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amanda L GillEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-5827-8265
William H HudsonEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Rajesh M ValanparambilEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Eunseon AhnEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Donald J McGuireEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Andreas WielandDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-9648-7922
Daniel T McManusEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Haydn T KissickEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Rama S AkondyTrivedi School of Biosciences, Ashoka University, Sonipat, Haryana, India.
Rafi AhmedEmory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-9591-2621

Funding

T CELL MEMORY TO VIRUSESR01AI030048 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AHMED, RAFI · 1990 to 2022
$5.2M
Control of CD8+ T cell exhaustion by novel checkpoint moleculesR00AI153736 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI HUDSON, WILLIAM HARRIS · 2022 to 2023
$498k
NIAID NIH HHS R00 AI153736NIAID NIH HHS R01 AI030048
6 · The paper itself

Abstract

Increased demand for novel, highly effective vaccination strategies necessitates a better understanding of long-lived memory CD8 T cell differentiation. To achieve this understanding, we used the mouse model of acute lymphocytic choriomeningitis virus (LCMV) infection. We reexamined classical memory CD8 T cell subsets and performed in-depth, longitudinal analysis of their phenotype, transcriptional programming, and anatomic location within the spleen. All analyses were performed at multiple time points from 8 days to 1 year postinfection. Memory subsets are conventionally defined by their expression of KLRG1 and IL-7Rα, as follows: KLRG1

Indexed as

Lymphocytic ChoriomeningitisT-Lymphocyte SubsetsAnimalsAntigens, SurfaceCD28 AntigensCD8-Positive T-LymphocytesImmunologic MemoryLectins, C-TypeLymphocytic choriomeningitis virusMiceMice, Inbred C57BLPhenotypeReceptors, ImmunologicReceptors, Interleukin-7TranscriptomeVaccinationAntigens, SurfaceCD28 Antigensinterleukin-7 receptor, alpha chainKlrg1 protein, mouseLectins, C-TypeReceptors, ImmunologicReceptors, Interleukin-7Viral VaccinesCD8 T cellslymphocytic choriomeningitis virusmemory cell differentiationvaccinesviral infection

Identifiers

PMID36541799
PMCPMC9888238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.