Evidence map›Paper›PMID 36541685›Full record

ArticleInternational wound journal2023

CCN1 secreted by human adipose-derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway.

Yi Yang, Shiyi Li, Xuer Sun, Lixia Zhang, Minliang Chen, Huijuan Fu

Open access · goldAbstract read
In one paragraph

Article in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yi YangSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-4127-377X
Shiyi LiSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Xuer SunSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Lixia ZhangSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Minliang ChenSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Huijuan FuSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to explore the role of cellular communication network factor 1 (CCN1) an extracellular matrix protein in hADSC-treated wound healing. Immunofluorescence and enzyme-linked immunosorbent assays (ELISA) were used to demonstrate the secretion of CCN1 by hADSCs, isolated from human fat tissue. We investigated the role of CCN1 in wound healing by knockdown of CCN1 expression in hADSCs using CCN1 siRNA. Conditioned medium of hADSCs or hADSCs with CCN1 knocked down (hADSC-CM

Indexed as

Cysteine-Rich Protein 61Endothelial CellsAdipose TissueAnimalsHumansMiceProto-Oncogene Proteins c-aktStem CellsWound HealingCCN1 protein, humanCysteine-Rich Protein 61Proto-Oncogene Proteins c-aktangiogenesisCCN1conditioned mediumhADSCswound healing

Identifiers

PMID36541685
PMCPMC10088821
OpenAlexW4312065732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.