Evidence map›Paper›PMID 36541483›Full record

ArticleCancer science2023

The oncogenic driving force of CD30 signaling-induced chromosomal instability in adult T-cell leukemia/lymphoma.

Makoto Nakashima, Atae Utsunomiya, Toshiki Watanabe, Ryouichi Horie, Kaoru Uchimaru

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Pathobiological link between CD30 and abnormal lymphocytes in adult T-cell leukemia/lymphoma.Journal of clinical and experimental hematopathology : JCEH · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Makoto NakashimaLaboratory of Tumor Cell Biology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-9843-9040
Atae UtsunomiyaDepartment of Hematology, Imamura General Hospital, Kagoshima, Japan.ORCID https://orcid.org/0000-0002-8843-406X
Toshiki WatanabeLaboratory of Practical Management of Medical Information, Graduate School of Medicine, St. Marianna University, Kawasaki, Kanagawa, Japan.
Ryouichi HorieDivision of Hematology, Department of Laboratory Sciences, School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan.ORCID https://orcid.org/0000-0002-2431-2290
Kaoru UchimaruLaboratory of Tumor Cell Biology, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPImamura Hospital · JPKitasato University · JPSt. Marianna University School of Medicine · JP

Funding

Japan Agency for Medical Research and Development 20fk0108126h0001Japan Agency for Medical Research and Development JP22fk0108124Japan Society for the Promotion of Science 19K16580Japan Society for the Promotion of Science 20K07379Japan Society for the Promotion of Science 22H04925Japan Society for the Promotion of Science 22K15420Japan Society for the Promotion of Science JP16H06277Takeda Pharmaceutical Company
6 · The paper itself

Abstract

Adult T-cell leukemia/lymphoma (ATL) develops via stepwise accumulation of gene mutations and chromosome aberrations. However, the molecular mechanisms underlying this tumorigenic process are poorly understood. We previously reported the presence of a biological link between the expression of CD30, which serves as a marker for ATL progression, and the actively proliferating fraction of human T-cell leukemia virus type 1 (HTLV-1)-infected cells that display polylobulation. Here, we demonstrated that CD30 signaling induced chromosomal instability with clonal expansion through DNA double-strand breaks (DSBs) via an increase of intracellular reactive oxygen species. CD30

Indexed as

Human T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellLymphomaAdultChromosomal InstabilityHumansSignal TransductionCD30 signalingchromosomal instabilityDNA double-strand breakslymphomagenesisreactive oxygen species

Identifiers

PMID36541483
PMCPMC10067402
OpenAlexW4312043261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.