Evidence map›Paper›PMID 36541099›Full record

ArticleOpen biology2022

Calcium regulates acid-sensing ion channel 3 activation by competing with protons in the channel pore and at an allosteric binding site.

Sophie Roy, Niklaus Johner, Viktor Trendafilov, Ivan Gautschi, Olivier Bignucolo, Ophélie Molton, Simon Bernèche, Stephan Kellenberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Acid-sensing ion channels and their role in controlling pain in the post-operative stage.International journal of physiology, pathophysiology and pharmacology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Regulation of Ion Homeostasis for Enhanced Tumor Radio-Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sophie RoyDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.
Niklaus JohnerSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0003-2257-7508
Viktor TrendafilovDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.
Ivan GautschiDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.
Olivier BignucoloDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0003-4735-049X
Ophélie MoltonDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.
Simon BernècheSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.ORCID 0000-0002-6274-4094
Stephan KellenbergerDepartment of biomedical Sciences, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0003-1755-6198
University of Lausanne · CHSIB Swiss Institute of Bioinformatics · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular Ca

Indexed as

Brain IschemiaStrokeAcid Sensing Ion ChannelsAllosteric SiteCalciumHumansHydrogen-Ion ConcentrationIonsProtonsAcid Sensing Ion ChannelsCalciumIonsProtonsactivationASICcalciumion channelmolecular dynamicspH dependence

Identifiers

PMID36541099
PMCPMC9768671
OpenAlexW4312071312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.