Evidence map›Paper›PMID 36540372›Full record

ArticleMathematics (Basel, Switzerland)2022

Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients.

Adequate Mhlanga, Rami Zakh, Alexander Churkin, Vladimir Reinharz, Jeffrey S Glenn, Ohad Etzion, Scott J Cotler, Cihan Yurdaydin, Danny Barash, Harel Dahari

Abstract read
In one paragraph

Article in Mathematics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adequate MhlangaThe Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.
Rami ZakhDepartment of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.
Alexander ChurkinDepartment of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel.
Vladimir ReinharzDepartment of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
Jeffrey S GlennDivision of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA.
Ohad EtzionDepartment of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Scott J CotlerThe Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.
Cihan YurdaydinDepartment of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey.
Danny BarashDepartment of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel.
Harel DahariThe Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA.

Funding

Data-Driven Mathematical and Computational Modeling of Hepatitis D Infection and Treatment ResponseR01AI146917 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL · 2020 to 2024
$3.5M
Collaborative Integration of Hepatitis B Molecular Virology and Mathematical/Computational ModelingR01AI144112 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL, UPRICHARD, SUSAN L. · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144112NIAID NIH HHS R01 AI146917
6 · The paper itself

Abstract

Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

Indexed as

analytical solutionanti-HDV treatmenthepatitis B virushepatitis delta virus

Identifiers

PMID36540372
PMCPMC9762680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.