Evidence map›Paper›PMID 36540355›Full record

ReviewStem cell investigation2022

Leukemic stem cells and advances in hematopoietic stem cell transplantation for acute myeloid leukemia: a narrative review of clinical trials.

Vikram Sumbly, Ian Landry, Christina Sneed, Qamar Iqbal, Anu Verma, Tenzin Dhokhar, Adeel Masood, Akshay Amaraneni

Open access · diamondAbstract readReview
In one paragraph

Review in Stem cell investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Vikram SumblyQueens Hospital Center, Jamaica, NY, USA.
Ian LandryQueens Hospital Center, Jamaica, NY, USA.
Christina SneedQueens Hospital Center, Jamaica, NY, USA.
Qamar IqbalTidalHealth Inc., Salisbury, MD, USA.
Anu VermaQueens Hospital Center, Jamaica, NY, USA.
Tenzin DhokharQueens Hospital Center, Jamaica, NY, USA.
Adeel MasoodTidalHealth Inc., Salisbury, MD, USA.
Akshay AmaraneniUniversity of Arizona Medical Center, Tucson, AZ, USA.
Queens Hospital Center · USBanner - University Medical Center Tucson · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this literature review is to summarize and provide a brief overview of our current understanding of acute myeloid leukemia (AML) and the role of stem cell transplantation (SCT) in its management. Background: AML is a malignant hematological disorder that is characterized by the uncontrolled proliferation of myeloid blood cells. This disease has been associated with various risk factors such as ionizing radiation, cigarette smoke, pesticides/herbicides, and chemotherapy. SCT remains the most beneficial treatment for medically fit AML patients due to superior survival outcomes. Methods: A thorough search was conducted on PubMed, Scopus, ClinicalTrials.gov, Embase and Web of Science using related keywords. Current articles on the uses of stem cell therapy in AML patients were selected. Conclusions: Long term exposure to ionizing radiation and other harmful substances such as benzene, cigarette smoke and chemotherapeutic drugs plays an important role in AML carcinogenesis. Mutations in certain genes (e.g.,

Indexed as

acute myeloid leukemia (AML)Cancer stem cells (CSC)malignant hematologystem cell transplantation (SCT)

Identifiers

PMID36540355
PMCPMC9760414
OpenAlexW4311522577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.