Evidence map›Paper›PMID 36540138›Full record

ArticleNeurology. Clinical practice2022

Self-Reported Severity and Causes of Traumatic Brain Injury in Patients With Epileptic or Functional Seizures.

L Brian Hickman, Akash B Patel, Ishita Dubey, Amir H Karimi, Xingruo Zhang, Emily A Janio, Corinne H Allas, Siddhanka S Sreenivasan, Janar Bauirjan, Shannon D'Ambrosio and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

L Brian HickmanDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Akash B PatelDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Ishita DubeyDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Amir H KarimiDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Xingruo ZhangDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Emily A JanioDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Corinne H AllasDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Siddhanka S SreenivasanDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Janar BauirjanDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Shannon D'AmbrosioDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.ORCID https://orcid.org/0000-0002-2129-4728
Mona Al BannaDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Andrew Y ChoDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
Jerome EngelDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
John M SternDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.ORCID https://orcid.org/0000-0002-3549-1642
Wesley T KerrDepartment of Neurology (LBH, ID, AHK, XZ, CHA, SSS, JE, JMS, WTK), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Internal Medicine (LBH), University of California at Irvine, Irvine, CA; Department of Psychiatry and Biobehavioral Sciences (ABP, EAJ, JB, SDA, MAB, AYC, JE, WTK), University of California Los Angeles, Los Angeles, CA; Department of Neurobiology (JE), David Geffen School of Medicine at UCLA, Los Angeles, CA; Brain Research Institute (JE), University of California Los Angeles, Los Angeles, CA; and Department of Neurology (WTK), University of Michigan, Ann Arbor, MI.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Although moderate and severe traumatic brain injury (TBI) can cause posttraumatic epilepsy (PTE), many patients with functional seizures (FS) also report a history of mild TBI. To determine whether features of TBI history differ between patients with epileptic seizures (ES) and FS, we compared patient reports of TBI severity, symptoms, and causes of injury. Methods: We recruited patients undergoing video-EEG evaluation for the diagnosis of ES, FS, mixed ES and FS, or physiologic seizure-like events at an academic, tertiary referral center. Patients and their caregivers were interviewed before final video-EEG diagnosis regarding their TBI histories, including concussive symptoms and causes of injury. Results: Of 506 patients, a greater percentage of patients with FS reported a history of TBI than patients with ES (70% vs 59%, aOR = 1.75 [95% CI: 1.00-3.05], Discussion: Our findings further the association of mild TBI with FS and prompt reconsideration of typical assumptions regarding the significance of a reported TBI history in patients with previously undifferentiated seizures. Although common in both groups, TBI with LOC less than 30 minutes and causes of injury that are commonly believed to be more severe were reported more frequently in FS than ES. This suggests that a patient or caregiver reporting of these features does not imply that PTE is a more probable diagnosis than FS. Although a history of TBI with LOC and presumed high-risk causes of injury intuitively raises suspicion for PTE, clinicians should be cautioned that these historical factors also were a frequent finding in patients with FS.

Identifiers

PMID36540138
PMCPMC9757118
OpenAlexW4307639358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.