Evidence map›Paper›PMID 36540110›Full record

ArticleNanoscale advances2022

Cytotoxic sub-nanometer aqueous platinum clusters as potential antitumoral agents.

Rossella Greco, Guillermo García-Lainez, Judit Oliver-Meseguer, Carlo Marini, Irene Domínguez, Miguel López-Haro, Juan Carlos Hernández-Garrido, José Pedro Cerón-Carrasco, Inmaculada Andreu, Antonio Leyva-Pérez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rossella GrecoInstituto de Tecnología Química (UPV-CSIC) Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas Avda. de los Naranjos s/n 46022 Valencia Spain anleyva@itq.upv.es.
Guillermo García-LainezInstituto de Investigación Sanitaria (IIS) La Fe, Unidad Mixta de Investigación UPV/IIS La Fe, Hospital Universitari i Politècnic La Fe Avenida de Fernando Abril Martorell 106 46026 Valencia Spain iandreur@qim.upv.es.
Judit Oliver-MeseguerInstituto de Tecnología Química (UPV-CSIC) Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas Avda. de los Naranjos s/n 46022 Valencia Spain anleyva@itq.upv.es.ORCID https://orcid.org/0000-0003-1555-3583
Carlo MariniCELLS-ALBA Synchrotron E-08290 Cerdanyola del Vallès Barcelona Spain.
Irene DomínguezDepartment of Chemistry and Physics, University of Almeria, Agrifood Campus of International Excellence ceiA3 04120 Almeria Spain.
Miguel López-HaroDepartamento de Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Río San Pedro 11510 Puerto Real Cádiz Spain.ORCID https://orcid.org/0000-0003-2560-8015
Juan Carlos Hernández-GarridoDepartamento de Ciencia de los Materiales e Ingeniería Metalúrgica y Química Inorgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Río San Pedro 11510 Puerto Real Cádiz Spain.ORCID https://orcid.org/0000-0001-8499-0395
José Pedro Cerón-CarrascoCentro Universitario de la Defensa, Academia General del Aire. Universidad Politécnica de Cartagena. C/ Coronel López Peña S/N Santiago de La Ribera, 30720 Murcia Spain.ORCID https://orcid.org/0000-0003-0668-9227
Inmaculada AndreuInstituto de Investigación Sanitaria (IIS) La Fe, Unidad Mixta de Investigación UPV/IIS La Fe, Hospital Universitari i Politècnic La Fe Avenida de Fernando Abril Martorell 106 46026 Valencia Spain iandreur@qim.upv.es.
Antonio Leyva-PérezInstituto de Tecnología Química (UPV-CSIC) Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas Avda. de los Naranjos s/n 46022 Valencia Spain anleyva@itq.upv.es.ORCID https://orcid.org/0000-0003-1063-5811

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ligand-free sub-nanometer metal clusters (MCs) of Pt, Ir, Rh, Au and Cu, are prepared here in neat water and used as extremely active (nM) antitumoral agents for HeLa and A2870 cells. The preparation just consists of adding the biocompatible polymer ethylene-vinyl alcohol (EVOH) to an aqueous solution of the corresponding metal salt, to give liters of a MC solution after filtration of the polymer. Since the MC solution is composed of just neat metal atoms and water, the intrinsic antitumoral activity of the different sub-nanometer metal clusters can now fairly be evaluated. Pt clusters show an IC

Identifiers

PMID36540110
PMCPMC9724608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.