Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients.

Michael H Farkas, Lara A Skelton, Sriganesh Ramachandra-Rao, Elizabeth Au, Steven J Fliesler

Abstract read

In one paragraph

Article in Molecular vision, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Exploring Recent Developments in the Manifestation, Diagnosis, and Treatment of Patients with Smith-Lemli-Opitz Syndrome: From Molecular Pathways to Clinical Innovations.International journal of molecular sciences · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael H FarkasDepartment of Ophthalmology (Ross Eye Institute), The State University of New York- University at Buffalo, Buffalo, NY.

Lara A SkeltonDepartment of Ophthalmology (Ross Eye Institute), The State University of New York- University at Buffalo, Buffalo, NY.

Sriganesh Ramachandra-RaoDepartment of Ophthalmology (Ross Eye Institute), The State University of New York- University at Buffalo, Buffalo, NY.

Elizabeth AuDepartment of Ophthalmology (Ross Eye Institute), The State University of New York- University at Buffalo, Buffalo, NY.

Steven J FlieslerDepartment of Ophthalmology (Ross Eye Institute), The State University of New York- University at Buffalo, Buffalo, NY.

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024

$33.8M

ISOPRENOID METABOLISM IN THE RETINAR01EY007361 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI FLIESLER, STEVEN J. · 1988 to 2015

$4.4M

NCATS NIH HHS UL1 TR001412NEI NIH HHS R01 EY007361

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Induced Pluripotent Stem CellsSmith-Lemli-Opitz SyndromeCholesterolGene Expression ProfilingHumansTranscriptomeCholesterol

Identifiers

PMID36540063

PMCPMC9744241

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.