Evidence map›Paper›PMID 36540052›Full record

ArticleJMIR formative research2023

Understanding Digital Mental Health Needs and Usage With an Artificial Intelligence-Led Mental Health App (Wysa) During the COVID-19 Pandemic: Retrospective Analysis.

Chaitali Sinha, Saha Meheli, Madhura Kadaba

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in JMIR formative research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167056 (Artificial Intelligence-Powered Support For Quality Of Life Improvement In Patients With Cancer), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07167056 narecruitingnot on this mapstarted 2025, after this paper: background citation

Artificial Intelligence-Powered Support For Quality Of Life Improvement In Patients With Cancer

TypeinterventionalSponsorCase Comprehensive Cancer CenterRan2025 to 2027Enrolled60ConditionsCancerArmsStandard of Care Psychotherapy, WYSA App
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  6. Review
  7. Extreme Weather, Vulnerable Populations, and Mental Health: The Timely Role of AI Interventions.International journal of environmental research and public health · 2025
    Article
  8. Chatbots and COVID-19: Taking Stock of the Lessons Learned.Journal of medical Internet research · 2024
    Article
  9. Fear of COVID-19 and PTSD: The Protective Function of Problem-Solving Appraisals in Mental Health.International journal of environmental research and public health · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chaitali SinhaWysa, Boston, MA, United States.ORCID https://orcid.org/0000-0001-8919-7134
Saha MeheliDepartment of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, India.ORCID https://orcid.org/0000-0001-7728-8581
Madhura KadabaWysa, Boston, MA, United States.ORCID https://orcid.org/0000-0001-7471-7272
National Institute of Mental Health and Neurosciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere has been a surge in mental health concerns during the COVID-19 pandemic, which has prompted the increased use of digital platforms. However, there is little known about the mental health needs and behaviors of the global population during the pandemic. This study aims to fill this knowledge gap through the analysis of real-world data collected from users of a digital mental health app (Wysa) regarding their engagement patterns and behaviors, as shown by their usage of the service.

objectiveThis study aims to (1) examine the relationship between mental health distress, digital health uptake, and COVID-19 case numbers; (2) evaluate engagement patterns with the app during the study period; and (3) examine the efficacy of the app in improving mental health outcomes for its users during the pandemic.

methodsThis study used a retrospective observational design. During the COVID-19 pandemic, the app's installations and emotional utterances were measured from March 2020 to October 2021 for the United Kingdom, the United States of America, and India and were mapped against COVID-19 case numbers and their peaks. The engagement of the users from this period (N=4541) with the Wysa app was compared to that of equivalent samples of users from a pre-COVID-19 period (1000 iterations). The efficacy was assessed for users who completed pre-post assessments for symptoms of depression (n=2061) and anxiety (n=1995) on the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) test measures, respectively.

resultsOur findings demonstrate a significant positive correlation between the increase in the number of installs of the Wysa mental health app and the peaks of COVID-19 case numbers in the United Kingdom (P=.02) and India (P<.001). Findings indicate that users (N=4541) during the COVID period had a significantly higher engagement than the samples from the pre-COVID period, with a medium to large effect size for 80% of these 1000 iterative samples, as observed on the Mann-Whitney test. The PHQ-9 and GAD-7 pre-post assessments indicated statistically significant improvement with a medium effect size (PHQ-9: P=.57; GAD-7: P=.56).

conclusionsThis study demonstrates that emotional distress increased substantially during the pandemic, prompting the increased uptake of an artificial intelligence-led mental health app (Wysa), and also offers evidence that the Wysa app could support its users and its usage could result in a significant reduction in symptoms of anxiety and depression. This study also highlights the importance of contextualizing interventions and suggests that digital health interventions can provide large populations with scalable and evidence-based support for mental health care.

Indexed as

chatbotconversational agentCOVID-19digital health interventiondigital mental healthengagementmental health appmobile healthpandemic wavesperceived needsretention

Identifiers

PMID36540052
PMCPMC9885755
OpenAlexW4312112956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.