ArticleInfection and immunity1987
Susceptibility of pathogenic and nonpathogenic Naegleria spp. to complement-mediated lysis.
Article in Infection and immunity, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency.medRxiv : the preprint server for health sciences · 2026Article
- Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri.BMC biology · 2021Article
- The genome of Naegleria lovaniensis, the basis for a comparative approach to unravel pathogenicity factors of the human pathogenic amoeba N. fowleri.BMC genomics · 2018Article
- Anti-GK1 antibodies damage Taenia crassiceps cysticerci through complement activation.Parasitology research · 2018Article
- Pathogenesis of acanthamoeba keratitis.The ocular surface · 2010Review
- Identification of a Naegleria fowleri membrane protein reactive with anti-human CD59 antibody.Infection and immunity · 2006Article
- Alterations in protein expression and complement resistance of pathogenic Naegleria amoebae.Infection and immunity · 1992Article
- Resistance of highly pathogenic Naegleria fowleri amoebae to complement-mediated lysis.Infection and immunity · 1989Article
- Immunoglobulin M-dependent classical complement pathway activation in killing of Pentatrichomonas hominis.Infection and immunity · 1989Article
- Depression of immunity to Naegleria fowleri in mice by selective depletion of neutrophils with a monoclonal antibody.Infection and immunity · 1988Article
- Biology of Naegleria spp.Microbiological reviews · 1988Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The susceptibility of four species of Naegleria amoebae to complement-mediated lysis was determined. The amoebicidal activity of normal human serum (NHS) and normal guinea pig serum (NGPS) for Naegleria amoebae was measured by an in vitro cytotoxicity assay. Release of radioactivity from amoebae labeled with [3H]uridine and visual observation with a compound microscope were used as indices of lysis. Highly pathogenic mouse-passaged N. fowleri was less susceptible to the lytic effects of NHS and NGPS than the weakly pathogenic, axenically grown N. fowleri or N. australiensis and the nonpathogenic amoebae N. gruberi and N. lovaniensis. However, both pathogenic and nonpathogenic Naegleria spp. depleted complement as assessed by total hemolytic activity. Treatment of serum with EDTA, heat (56 degrees C, 30 min), cobra venom factor, or antibody to C3 or C9 complement components decreased the amoebicidal activity of NHS. The presence of specific agglutinating antibody to N. fowleri enhanced the amoebicidal activity of NGPS for N. fowleri.
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Registered trials
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