Evidence map›Paper›PMID 36539791›Full record

ArticleTrials2022

Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults-the TAKEOVER study.

Hannah Lithgow, Lynsey Johnston, Frederick K Ho, Carlos Celis-Morales, James Cobley, Truls Raastad, Angus M Hunter, Jennifer S Lees, Patrick B Mark, Terry J Quinn and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04676958 (Effects of Vitamin K2 on Recovery From Muscle Damaging Exercise in Young and Older Adults), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04676958 nacompletednot on this map

Effects of Vitamin K2 on Recovery From Muscle Damaging Exercise in Young and Older Adults

TypeinterventionalSponsorUniversity of GlasgowRan2021 to 2023Enrolled80ConditionsInflammation, Oxidative Stress, Vitamin K, ExerciseArmsVitamin K2, Micro-crystalline cellulose
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Hannah LithgowSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK.
Lynsey JohnstonSchool of Life Sciences, University of Glasgow, Glasgow, UK.
Frederick K HoSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Carlos Celis-MoralesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK.
James CobleyDivision of Biomedical Sciences, University of Highlands and Islands, Inverness, UK.
Truls RaastadDepartment of Physical Performance, Norwegian School of Sports Science, Oslo, Norway.
Angus M HunterDepartment of Sprots Science, Nottingham Trent University, Nottingham, UK.
Jennifer S LeesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK.
Patrick B MarkSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK.
Terry J QuinnSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK.
Stuart R GraySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, G12 8TA, UK. stuart.gray@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-8969-9636
University of Glasgow · GBLithuanian University of Health Sciences · LTNorwegian School of Sport Sciences · NONottingham Trent University · GBUniversity of the Highlands and Islands · GB

Funding

Kappa Bioscience NA
6 · The paper itself

Abstract

backgroundRegular participation in resistance exercise is known to have broad-ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults.

methodsThe current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain-free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress. DISCUSSION: Ethical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through a presentation at scientific conferences and in scientific journals.

trial registrationClinicialTrials.gov NCT04676958. Prospectively registered on 21 December 2020.

Indexed as

Resistance TrainingAgedExerciseHumansMuscle, SkeletalMuscle StrengthRandomized Controlled Trials as TopicVitamin K 2Vitamin K 2InflammationMuscle damageRecoveryResistance exerciseVitamin K

Identifiers

PMID36539791
PMCPMC9764575
OpenAlexW4312114005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.