Evidence map›Paper›PMID 36539788›Full record

ArticleInternational breastfeeding journal2022

How much does a liter of donor human milk cost? Cost analysis of operating a human milk bank in Italy.

Guglielmo Salvatori, Domenico Umberto De Rose, Maria Clemente, Cristina Gentili, Giovanni Paride Verardi, Patrizia Amadio, Maria Paola Reposi, Pietro Bagolan, Andrea Dotta

Open access · goldAbstract read
In one paragraph

Article in International breastfeeding journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Cost of operating a human milk bank in the UK: a microcosting analysis.Archives of disease in childhood. Fetal and neonatal edition · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Guglielmo SalvatoriNeonatal Intensive Care Unit and Human Milk Bank, Medical and Surgical Department of Fetus - Newborn - Infant, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Domenico Umberto De RoseNeonatal Intensive Care Unit and Human Milk Bank, Medical and Surgical Department of Fetus - Newborn - Infant, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy. domenico.derose@opbg.net.
Maria ClementeNeonatal Intensive Care Unit and Human Milk Bank, Department of Life and Reproductive Sciences, Verona Hospital, Verona, Italy.
Cristina GentiliFinance Control, Internal Control, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Giovanni Paride VerardiFinance Control, Internal Control, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Patrizia AmadioNeonatal Intensive Care Unit and Human Milk Bank, Medical and Surgical Department of Fetus - Newborn - Infant, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Maria Paola ReposiNeonatal Intensive Care Unit and Human Milk Bank, Medical and Surgical Department of Fetus - Newborn - Infant, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Pietro BagolanNeonatal Surgery Unit, Medical and Surgical Department of Fetus - Newborn - Infant, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Andrea DottaNeonatal Intensive Care Unit and Human Milk Bank, Medical and Surgical Department of Fetus - Newborn - Infant, "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.
Bambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, 40 Human Milk Banks (HMB) have been established in Italy; however, recent cost analysis data for operating an HMB in Italy are not available in the literature.

methodsThis study was a cross-sectional study performed at "Bambino Gesù" Children's Hospital in Rome, Italy in 2019. We assessed the one-year operational costs and, the per liter unit costs at our HMB.

resultsDuring the 2019 year we collected 771 l of human milk supplied by 128 donors. The total cost was € 178,287.00 and the average cost was € 231.00 per liter. € 188,716.00 would have been spent had the maximum capacity for 904 l been reached. We found a significant difference (€ 231.00 vs € 209.00 per liter, p = 0.016) comparing the cost for collected liters in the year 2019 and the cost for the maximum capacity of the bank for that year of activity. Analyzing each cost item that determines the charge of donor human milk (DHM), the highest costs are the salaries of medical and paramedical staff, and then the costs related to transporting. If the HMB works at maximum capacity and manages a greater number of liters of milk, this can represent an important saving. Conversely, the price of consumables is modest (i.e., the price of a single-use kit for breast pumps was € 0.22 per unit).

conclusionThe costs for a liter of DHM are quite high, but they must be related to the benefits, especially for preterm infants. Comparing the cost for collected liters in 2019 and the costs for the 2019 maximum capacity of the HMB, we calculated how much fixed costs of collection and distribution of DHM can be reduced, by increasing the volume of milk collected. To the best of our knowledge, this is the first complete cost analysis for an Italian Milk Bank. A thorough analysis could help to abate fixed costs and reduce the cost of a liter of DHM. The centralization of DHM can allow savings, rather than creating small HMBs scattered throughout the territory that would operate with lower milk volumes.

Indexed as

Milk BanksMilk, HumanBreast FeedingChildCosts and Cost AnalysisCross-Sectional StudiesFemaleHumansInfantInfant, NewbornInfant, PrematureItalyDonor human milkHuman milk bankNewborn

Identifiers

PMID36539788
PMCPMC9764658
OpenAlexW4313438485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.