Evidence map›Paper›PMID 36539756›Full record

ArticleBMC psychiatry2022

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol.

Hayley Denyer, J Antoni Ramos-Quiroga, Amos Folarin, Carolina Ramos, Petra Nemeth, Andrea Bilbow, Euan Woodward, Susannah Whitwell, Ulrich Müller-Sedgwick, Henrik Larsson and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Observational
  9. LOTUS Software to Process Wearable EmbracePlus Data.Sensors (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Attention-deficit/hyperactivity disorder.Nature reviews. Disease primers · 2024
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Hayley DenyerSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK. hayley.denyer@kcl.ac.uk.ORCID 0000-0002-1942-7325
J Antoni Ramos-QuirogaDepartment of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain.
Amos FolarinDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Carolina RamosGroup of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.
Petra NemethEmpatica Srl, Milan, Italy.
Andrea BilbowThe National Attention Deficit Disorder Information and Support Service, ADDISS, Edgware, Middlesex, UK.
Euan WoodwardEuropean Association for the Study of Obesity - Ireland, Dublin, Ireland.
Susannah WhitwellSouth London and Maudsley NHS Foundation Trust, London, UK.
Ulrich Müller-SedgwickAdult Neurodevelopmental Service, Health and Community Services, Government of Jersey, St Helier, Jersey.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Richard Jb DobsonDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-4224-9245
Jonna KuntsiSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, London, UK.ORCID 0000-0002-0113-8162
King's College London · GBUniversity of London · GBEdgware Community Hospital · GBEuropean Association for the Study of Obesity · GBÖrebro University · SESouth London and Maudsley NHS Foundation Trust · GBUniversitat Autònoma de Barcelona · ESUniversity of Cambridge · GBVall d'Hebron Institut de Recerca · ES

Funding

European Commission 965381Medical Research Council MC_PC_17214Medical Research Council MR/N013700/1
6 · The paper itself

Abstract

backgroundEmerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA) project uses remote measurement technology to obtain real-world data from daily life to assess the extent to which ADHD medication treatment and physical activity, individually and jointly, may influence cardiometabolic risks in adults with ADHD. Our second main aim is to obtain valuable real-world data on adherence to pharmacological treatment and its predictors and correlates during daily life from adults with ADHD.

methodsART-CARMA is a multi-site prospective cohort study within the EU-funded collaboration 'TIMESPAN' (Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients) that will recruit 300 adults from adult ADHD waiting lists. The participants will be monitored remotely over a period of 12 months that starts from pre-treatment initiation. Passive monitoring, which involves the participants wearing a wrist-worn device (EmbracePlus) and downloading the RADAR-base Passive App and the Empatica Care App on their smartphone, provides ongoing data collection on a wide range of variables, such as physical activity, sleep, pulse rate (PR) and pulse rate variability (PRV), systolic peaks, electrodermal activity (EDA), oxygen saturation (SpO2), peripheral temperature, smartphone usage including social connectivity, and the environment (e.g. ambient noise, light levels, relative location). By combining data across these variables measured, processes such as physical activity, sleep, autonomic arousal, and indicators of cardiovascular health can be captured. Active remote monitoring involves the participant completing tasks using a smartphone app (such as completing clinical questionnaires or speech tasks), measuring their blood pressure and weight, or using a PC/laptop (cognitive tasks). The ART system is built on the RADAR-base mobile-health platform. DISCUSSION: The long-term goal is to use these data to improve the management of cardiometabolic disease in adults with ADHD, and to improve ADHD medication treatment adherence and the personalisation of treatment.

Indexed as

Attention Deficit Disorder with HyperactivityCardiovascular DiseasesAdultCardiometabolic Risk FactorsHumansMedication AdherenceMulticenter Studies as TopicProspective StudiesADHDAttention deficit hyperactivity disorderCardiovascular diseaseDigital phenotypingMedication adherencemHealthRemote measurement technologyRemote monitoring

Identifiers

PMID36539756
PMCPMC9764531
OpenAlexW4312113531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.