Observational studyBMC ophthalmology2022
Analysis of macular blood flow changes in thyroid associated ophthalmopathy.
Observational study in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Optical coherence tomography angiography in thyroid associated ophthalmopathy: a systematic review.BMC ophthalmology · 2024Pooled it
- Effects of endoscopic transnasal orbital decompression on anterior segment ocular blood flow and clinical outcome in thyroid-associated ophthalmopathy: a retrospective study.American journal of translational research · 2026Article
- Associations between axial length and optical coherence tomography angiography biomarkers.International journal of retina and vitreous · 2025Article
- Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography.BMC medical imaging · 2025Article
- Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST.Ophthalmology and therapy · 2024Article
- Orbital decompression improves visual function and macular blood perfusion status in patients with thyroid-related eye disease.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo evaluate the changes in macular superficial retinal vessel density and their relation with visual acuity in thyroid-associated ophthalmopathy (TAO) patients with different severity.
methodsThis cross-sectional observational study included 70 TAO patients and 70 healthy controls. Only data from the right eyes were analyzed. TAO patients were divided into 7 subgroups according to the NOSPECS score. Foveal avascular zone (FAZ), vascular density (VD), and perfusion density (PD) of macular 1 mm diameter and 6 mm diameter areas were measured by optical coherence tomography angiography (OCTA).
resultsIn TAO patients, significant increases were found in macular and foveal vascular densities (FVD) and perfusion densities (FPD) while a significant decrease was found in the FAZ area when compared with the control group (p < 0.05). Spearman correlation analysis and multiple linear regression analysis showed that TAO severity grade was negatively correlated with FVD (β = -1.150, p = 0.032), FPD (β = -0.024, p = 0.042), MVD (β = -0.583, p = 0.020) and MPD (β = -0.011, p = 0.010). Clinical activity score (CAS) score showed positive correlation with FVD (β = 0.794, p = 0.035) and FPD(β = 0.017, p = 0.041). FVD (β = -0.009, p = 0.033), MVD(β = -0.034, p < 0.001), FPD(β = -0.416, p = 0.039) and MPD(β = -2.428, p < 0.001) all showed negative correlation with best corrected visual acuity (BCVA).
conclusionsThere was an overall increase in superficial macular blood flow in TAO patients compared with healthy controls and the blood flow decreased as TAO got worse. Superficial macular flow density was negatively correlated with BCVA.
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