ArticleBMC pediatrics2022
Lactate/albumin ratio as a predictor of in-hospital mortality in critically ill children.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 15 citations in OpenAlex.
- Lactate-albumin ratio as an early predictor of mortality in critically ill children: A prospective cohort study.European journal of pediatrics · 2026Article
- Lactate-to-albumin ratio, C-reactive protein-to-albumin ratio, and prognostic nutritional index in acute and critical care: A focused mini-review.World journal of critical care medicine · 2026Review
- Machine Learning-Augmented Traditional Analysis of Lactate vs Lactate-to-Albumin Ratio for Predicting Mortality Risk in Patients With Sepsis: Large-Scale Retrospective Study.JMIR medical informatics · 2026Observational
- Lactate-albumin ratio measurements at multiple time points and their association with outcome in pediatric trauma: a PICU-based study.BMC pediatrics · 2026Observational
- Association between lactate dehydrogenase to serum albumin ratio and all-cause mortality among critically ill pediatrics: a retrospective cohort study.BMC pediatrics · 2026Article
- Predictive value of the lactate dehydrogenase to albumin ratio for coronary artery lesions and IVIG resistance in Kawasaki disease.BMC pediatrics · 2026Article
- The correlation of lactate/albumin ratio and their association for short-term and long-term mortality in patients with acute aortic dissection.JTCVS open · 2026Article
- Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis.Frontiers in pediatrics · 2026Article
- Development and Validation of a Prediction Model for Early ARDS in Children with Sepsis in the PICU: A Multicenter Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2026Article
- Prognostic implications of lactate dehydrogenase-to-albumin ratio in pediatric intensive care unit patients: a single-center prospective study.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Article
- L-shaped association between fibrinogen to serum albumin ratio and all-cause mortality among critically ill children: a retrospective cohort study.BMC pediatrics · 2025Article
- Association between lactate-to-albumin ratio and all-cause mortality in critically ill cirrhotic patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC gastroenterology · 2025Article
- Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis.BMC pediatrics · 2025Article
- Article
- Association between lactate-to-albumin ratio and 28-day ICU mortality in pediatric severe pneumonia patients.PloS one · 2025Article
- Predictive accuracy of lactate albumin ratio for mortality in intensive care units: a nationwide cohort study.BMJ open · 2024Article
- Association between the lactate-albumin ratio and microcirculation changes in Pediatric Septic patients.Scientific reports · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveManaging critically ill patients with high mortality can be difficult for clinicians in pediatric intensive care units (PICU), which need to identify appropriate predictive biomarkers. The lactate/albumin (L/A) ratio can precisely stratify critically ill adults. However, the role of the L/A ratio in predicting the outcomes of critically ill children remains unclear. Therefore, this study aimed to evaluate the prognostic performance of the L/A ratio in predicting in-hospital mortality in unselected critically ill patients in the PICU.
methodsThis was a single-center retrospective study. Clinical data of 8,832 critical patients aged between 28 days and 18 years were collected from the pediatric intensive care (PIC) database from 2010 to 2018. The primary outcome was the in-hospital mortality rate.
resultsThere was a higher level of L/A ratio in non-survivors than survivors (P < 0.001). Logistic regression indicated that the association between the L/A ratio and in-hospital mortality was statistically significant (OR 1.44, 95% CI 1.31-1.59, P < 0.001). The AUROC of the L/A ratio for predicting in-hospital mortality was higher than lactate level alone (0.74 vs 0.70, P < 0.001). Stratification analysis showed a significant association between the L/A ratio and in-hospital mortality in the age and primary disease groups (P < 0.05).
conclusionsOur study suggested that the L/A ratio was a clinical tool to predict in-hospital mortality in critically ill children better than lactate level alone. However, given that the study was retrospective, more prospective studies should be conducted to test the predictive value of the L/A ratio in critical illness.
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