Evidence map›Paper›PMID 36539590›Full record

Trial reportGeroScience2023

Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial.

Nick W Bray, Frederico Pieruccini-Faria, Suzanne T Witt, Kenneth Rockwood, Robert Bartha, Timothy J Doherty, Lindsay S Nagamatsu, Quincy J Almeida, Teresa Liu-Ambrose, Laura E Middleton and 2 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02808676 (SYNchronizing Exercises, Remedies in GaIt and Cognition), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02808676 naterminatednot on this map

SYNchronizing Exercises, Remedies in GaIt and Cognition (SYNERGIC): A Randomized Controlled Double Blind Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2016 to 2020Enrolled175ConditionsMild Cognitive ImpairmentArmsVitamin D3, Exercises (E), Cognitive Training (CT), placebo D3, control cognitive training
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Nick W BrayCumming School of Medicine, Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, T2N 1N4, Canada. nicholas.bray@ucalgary.ca.ORCID http://orcid.org/0000-0001-5831-7842
Frederico Pieruccini-FariaGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada.
Suzanne T WittBrainsCAN, Western University, London, ON, N6A-3K7, Canada.
Kenneth RockwoodDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.
Robert BarthaDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.
Timothy J DohertyDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A-5C1, Canada.
Lindsay S NagamatsuFaculty of Health Sciences, School of Kinesiology, Western University, London, ON, N6G-2V4, Canada.
Quincy J AlmeidaFaculty of Science, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, N2L-3C5, Canada.
Teresa Liu-AmbroseDepartment of Physical Therapy, University of British Columbia, BC, V6T-1Z3, Vancouver, Canada.
Laura E MiddletonDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L-3G1, Canada.
Louis BhererDepartment of Medicine, University of Montréal, Montréal, QC, H3T-1J4, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institute, Lawson Health Research Institute, 550 Wellington Road, Room A3-116, London, ON, N6C-0A7, Canada. mmontero@uwo.ca.ORCID http://orcid.org/0000-0002-5796-2361
Western University · CADalhousie University · CAMontreal Heart Institute · CAUniversity of Calgary · CAUniversity of Waterloo · CAVancouver Coastal Health · CAWilfrid Laurier University · CA

Funding

CIHR MOP 211220CIHR PJT 153100
6 · The paper itself

Abstract

Functional brain connectivity (FBC), or areas that are anatomically separate but temporally synchronized in their activation, represent a sensitive biomarker for monitoring dementia progression. It is unclear whether frailty is associated with FBC in those at higher risk of progression to dementia (e.g., mild cognitive impairment -MCI-) and if sex plays a role. We used baseline data from the SYNERGIC trial, including participants with MCI that received brain MRI. In this cross-sectional analyses (n = 100), we measured frailty using a deficit accumulation frailty index. Using the CONN toolbox, we assessed FBC of networks and regions of interest across the entire connectome. We used Pearson's correlation to investigate the relationship between FBC and frailty index in the full sample and by sex. We also divided the full sample and each sex into tertiles based upon their frailty index score and then assessed between-tertile differences in FBC. The full sample (cluster: size = 291 p-FDR < 0.05) and males (cluster: size = 993 and 451 p-FDR < 0.01) demonstrated that increasing (stronger) connectivity between the right hippocampus and clusters in the temporal gyrus was positively correlated with increasing (worse) frailty. Males also demonstrated between-tertile differences in right hippocampus connectivity to clusters in the lateral occipital cortex (cluster: size = 289 p-FDR < 0.05). Regardless of frailty status, females demonstrated stronger within-network connectivity of the Default-Mode (p = 0.024). Our results suggest that increasing (worse) frailty was associated with increasing (stronger) connectivity between regions not typically linked, which may reflect a compensation tactic by the plastic brain. Furthermore, the relationship between the two variables appears to differ by sex. Our results may help elucidate why specific individuals progress to a dementia syndrome. NCT02808676. https://www.clinicaltrials.gov/ct2/show/NCT02808676.

Indexed as

Cognitive DysfunctionDementiaFrailtyAgedBrainCross-Sectional StudiesFemaleHumansMaleCross-sectionalfMRIFrailtyFunctional brain connectivityMild cognitive impairmentOlder adults

Identifiers

PMID36539590
PMCPMC9767804
OpenAlexW4312032193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.