Evidence map›Paper›PMID 36539586›Full record

ArticleBiomolecular NMR assignments2023

Katherine M Coburn, Braden Roth, Kristen M Varney, France Carrier, David J Weber

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katherine M CoburnDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, 21201, Baltimore, MD, USA.
Braden RothDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, 21201, Baltimore, MD, USA.
Kristen M VarneyDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, 21201, Baltimore, MD, USA.
France CarrierDepartment of Radiation Oncology, University of Maryland School of Medicine, 655 West Baltimore, Street, 21201, Baltimore, MD, USA.
David J WeberDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, 21201, Baltimore, MD, USA. dweber@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Rational targeting of protein translation of cancer treatmentsR01CA177981 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CARRIER, FRANCE, WEBER, DAVID JOSEPH · 2013 to 2017
$1.6M
600 MHZ NMR SPECTROMETERS10RR010441 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 1995 to 1995
–
6 · The paper itself

Abstract

Heterogeneous ribonuclear protein A18 (hnRNP A18) is an RNA binding protein (RBP) involved in the hypoxic cellular stress response and regulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression in melanoma, breast cancer, prostate cancer, and colon cancer solid tumors. hnRNP A18 is comprised of an N-terminal structured RNA recognition motif (RMM) and a C-terminal intrinsically disordered domain (IDD). Upon cellar stressors, such as UV and hypoxia, hnRNP A18 is phosphorylated by casein kinase 2 (CK2) and glycogen synthase kinase 3β (GSK-3β). After phosphorylation, hnRNP A18 translocates from the nucleus to the cytosol where it interacts with pro-survival mRNA transcripts for proteins such as hypoxia inducible factor 1α and CTLA-4. Both the hypoxic cellular response and modulation of immune checkpoints by cancer cells promote chemoradiation resistance and metastasis. In this study, the

Indexed as

Carrier ProteinsHeterogeneous-Nuclear RibonucleoproteinsCTLA-4 AntigenGlycogen Synthase Kinase 3 betaHumansMaleNuclear Magnetic Resonance, BiomolecularProtein BindingRNA, MessengerCarrier ProteinsCTLA-4 AntigenGlycogen Synthase Kinase 3 betaHeterogeneous-Nuclear RibonucleoproteinsRNA, MessengerCIRBP (cold inducible RNA binding protein)hnRNP A18 (heterogeneous ribonucleoprotein A18)IDD (intrinsically disordered domain)RBP (RNA binding protein)

Identifiers

PMID36539586
PMCPMC10232570
OpenAlexW4312032141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.