Evidence map›Paper›PMID 36539440›Full record

ArticleScientific reports2022

Nanofiber formation as a promising technology for preservation and easy storage of extracellular vesicles.

Krisztina Németh, Adrienn Kazsoki, Tamás Visnovitz, Balázs Pinke, László Mészáros, Edit I Buzás, Romána Zelkó

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Krisztina Németh *Department of Genetics Cell and Immunobiology, Semmelweis University, Nagyvárad Square 4, Budapest, 1089, Hungary.
Adrienn Kazsoki *University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, 1092, Hungary.
Tamás VisnovitzDepartment of Genetics Cell and Immunobiology, Semmelweis University, Nagyvárad Square 4, Budapest, 1089, Hungary.
Balázs PinkeDepartment of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, 1111, Hungary.
László MészárosDepartment of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem Rkp. 3, Budapest, 1111, Hungary.
Edit I BuzásDepartment of Genetics Cell and Immunobiology, Semmelweis University, Nagyvárad Square 4, Budapest, 1089, Hungary. buzas.edit@med.semmelweis-univ.hu.
Romána ZelkóUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, Budapest, 1092, Hungary. zelko.romana@pharma.semmelweis-univ.hu.
Semmelweis University · HUBudapest University of Technology and Economics · HUEötvös Loránd University · HUMontavid Thermodynamic Research Group · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived, membrane-enclosed particles with the potential for a wide range of future therapeutic applications. However, EVs have almost always been administered by direct injection, likely hindering their efficacy because of rapid clearance from the injection site. The present study aimed to incorporate medium-sized extracellular vesicles (mEVs) into fast-dissolving electrospun polyvinylpyrrolidone-based nanofibers to explore the storage-dependent structure-activity relationship of the resulting nanofibrous formulations. Aqueous polyvinylpyrrolidone-based precursor solutions were selected for the electrospinning process. The presence of EVs in the electrospun samples was confirmed by transmission electron microscopy, flow cytometry, and confocal laser scanning microscope. The results indicate that the fibrous structure of the samples was preserved until the end of the 12-week storage period. Furthermore, regardless of the storage temperature (4 °C or room temperature), nanofibers and nanofiber-associated EVs were present throughout the experimental period. Incorporating EVs into a stable solid polymeric delivery base could preserve their stability; meanwhile, according to the characteristics of the polymer, their targeted and controlled release can be achieved.

Indexed as

Extracellular VesiclesNanofibersPolymersPovidoneTechnologyPolymersPovidone

Identifiers

PMID36539440
PMCPMC9768167
OpenAlexW4312082422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.