ArticleNature communications2022
Hippocampus as a sorter and reverberatory integrator of sensory inputs.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- An alternative inhibitory avoidance task for studying hippocampus-dependent spatial aversive memory in mice.Molecular brain · 2026Article
- The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics.Molecular brain · 2025Article
- Scaling of Ventral Hippocampal Activity during Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structural and functional changes in the hippocampus induced by environmental exposures.Neurosciences (Riyadh, Saudi Arabia) · 2025Review
- Link Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain.Neuroscience bulletin · 2024Article
- Prefrontal coding of learned and inferred knowledge during REM and NREM sleep.Nature communications · 2024Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.Molecular brain · 2023Article
- Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.Biology open · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus must be capable of sorting and integrating multiple sensory inputs separately but simultaneously. However, it remains to be elucidated how the hippocampus executes these processes simultaneously during learning. Here we found that synchrony between conditioned stimulus (CS)-, unconditioned stimulus (US)- and future retrieval-responsible cells occurs in the CA1 during the reverberatory phase that emerges after sensory inputs have ceased, but not during CS and US inputs. Mutant mice lacking N-methyl-D-aspartate receptors (NRs) in CA3 showed a cued-fear memory impairment and a decrease in synchronized reverberatory activities between CS- and US-responsive CA1 cells. Optogenetic CA3 silencing at the reverberatory phase during learning impaired cued-fear memory. Thus, the hippocampus uses reverberatory activity to link CS and US inputs, and avoid crosstalk during sensory inputs.
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