Evidence map›Paper›PMID 36539162›Full record

ArticleNeurochemistry international2023

Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.

Yu Feng, Luodan Yang, Xiaohui Ma, Zhihai Huang, Xuemei Zong, Cristiane Teresinha Citadin, Hung Wen Lin, Quanguang Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yu FengDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Luodan YangDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Xiaohui MaDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Zhihai HuangDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Xuemei ZongDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Cristiane Teresinha CitadinDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA; Department of Cellular Biology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Hung Wen LinDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA.
Quanguang ZhangDepartment of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, 1501 Kings Highway, LA, 71103, USA. Electronic address: quanguang.zhang@lsuhs.edu.
Louisiana State University Health Sciences Center Shreveport · US

Funding

Low Level Laser Therapy in Alzheimer's DiseaseRF1AG058603 · NIA · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, QUANGUANG · 2018 to 2018
$1.9M
NIA NIH HHS RF1 AG058603
6 · The paper itself

Abstract

The beneficial effects of photobiomodulation (PBM) on function recovery after stroke have been well-established, while its molecular and cellular mechanisms remain to be elucidated. The current study was designed to investigate the effect of PBM on synaptic proteins and astrocyte polarization of photothrombotic (PT)-stroke induced rats in vivo, and explore the possible effect of PBM treatment on oxygen-glucose deprivation (OGD)-induced neurotoxic astrocytic polarization in vitro. We reported that 2-min PBM treatment (808 nm) for 7 days significantly increased synaptic proteins and neuroprotective astrocytic marker S100 Calcium Binding Protein A10 (S100A10) and inhibited neurotoxic astrocytic marker C3d in the peri-infarct region after ischemic stroke. Cell culture studies of primary cortical neurons and N2a cells showed that single-dose PBM treatment could increase cellular viability, regulate the apoptotic proteins (Caspase 9, Bcl-xL and BAX) and preserve synaptic proteins following OGD exposure. Additionly, PBM decreased the levels of C3d, inducible nitric oxide synthase (iNOS) and interleukin 1β (IL-1β) on astrocytes exposed to OGD. In summary, we demonstrated that PBM could inhibit neurotoxic astrocytic polarization, preserve synaptic integrity and protect neurons against stroke injury both in vitro and in vivo.

Indexed as

AstrocytesStrokeAnimalsApoptosis Regulatory ProteinsGlucoseNeuronsOxygenRatsApoptosis Regulatory ProteinsGlucoseOxygenAstrocytic polarizationNeuroprotectionOxygen glucose deprivation (OGD)PhotobiomodulationStroke

Identifiers

PMID36539162
PMCPMC12798860
OpenAlexW4311817926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.