Evidence map›Paper›PMID 36539107›Full record

ArticleClinical immunology (Orlando, Fla.)2023

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19.

Weng Hua Khoo, Katherine Jackson, Chansavath Phetsouphanh, John J Zaunders, José Alquicira-Hernandez, Seyhan Yazar, Stephanie Ruiz-Diaz, Mandeep Singh, Rama Dhenni, Wunna Kyaw and 28 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 7 institutions in 1 country.

Weng Hua KhooGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Katherine JacksonGarvan Institute of Medical Research, Sydney, Australia.
Chansavath PhetsouphanhKirby Institute, UNSW Sydney, Sydney, Australia.
John J ZaundersCentre for Applied Medical Research, St Vincent's Hospital, Sydney, Australia.
José Alquicira-HernandezGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Seyhan YazarGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia.
Stephanie Ruiz-DiazGarvan Institute of Medical Research, Sydney, Australia.
Mandeep SinghGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Rama DhenniGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Wunna KyawGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Fiona TeaBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
Vera MerhebBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
Fiona X Z LeeBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
Rebecca BurrellSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Annaleise Howard-JonesKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Archana KoiralaKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Li ZhouKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Aysen YukselKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Daniel R CatchpooleKids Research, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Sydney, Australia.
Catherine L LaiKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Tennille L VitaglianoKids Research, The Children's Hospital at Westmead, Sydney, Australia.
Romain RouetGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Daniel ChristGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Benjamin TangDepartment of Intensive Care Medicine, Nepean Hospital, Sydney, Australia; Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research, Sydney, Australia; Respiratory Tract Infection Research Node, Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney, Australia.
Nicholas P WestSystems Biology and Data Science, Menzies Health Institute QLD, Griffith University, Parklands, Australia.
Shane GeorgeDepartments of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, QLD, Australia; School of Medicine and Menzies Health Institute Queensland, Griffith University, Southport, QLD, Australia.
John GerrardDepartment of Infectious Diseases and Immunology, Gold Coast University Hospital, Southport, QLD, Australia.
Peter I CroucherGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Anthony D KelleherKirby Institute, UNSW Sydney, Sydney, Australia.
Christopher G GoodnowGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia; UNSW Cellular Genomics Futures Institute, UNSW Sydney, Sydney, Australia.
Jonathan D SprentGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Joseph E PowellGarvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia; UNSW Cellular Genomics Futures Institute, UNSW Sydney, Sydney, Australia.
Fabienne BrilotBrain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, Australia; Brain and Mind Centre, The University of Sydney, Sydney, Australia.
Ralph NananCharles Perkins Centre Nepean, University of Sydney, Sydney, Australia.
Peter S HsuKids Research, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Sydney, Australia.
Elissa K DeenickGarvan Institute of Medical Research, Sydney, Australia; Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Philip N BrittonSydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; The Children's Hospital at Westmead, Sydney Children's Hospitals Network, Sydney, Australia.
Tri Giang PhanGarvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia. Electronic address: t.phan@garvan.org.au.
Children's Hospital at Westmead · AUGarvan Institute of Medical Research · AUUniversity of Sydney · AUSt Vincent's Hospital Sydney · AUUNSW Sydney · AUGriffith University · AUSt Vincent's Clinic · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immunity are beginning to be uncovered. We show by longitudinal multimodal analysis that SARS-CoV-2 leaves a small footprint in the circulating T cell compartment in children with mild/asymptomatic COVID-19 compared to adult household contacts with the same disease severity who had more evidence of systemic T cell interferon activation, cytotoxicity and exhaustion. Children harbored diverse polyclonal SARS-CoV-2-specific naïve T cells whereas adults harbored clonally expanded SARS-CoV-2-specific memory T cells. A novel population of naïve interferon-activated T cells is expanded in acute COVID-19 and is recruited into the memory compartment during convalescence in adults but not children. This was associated with the development of robust CD4

Indexed as

COVID-19AdultAntibodies, ViralCD4-Positive T-LymphocytesHumansImmunity, CellularLymphocyte ActivationSARS-CoV-2Antibodies, ViralClonal dynamicsCOVID-19Interferon-activated naive T cellsMemory T cellsSARS-CoV-2Single cell transcriptomicsT cell receptor repertoire

Identifiers

PMID36539107
PMCPMC9758763
OpenAlexW4313216272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.