ArticleHuman genetics1987
A comparative mapping study of fragile sites in the human and murine genomes.
Article in Human genetics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 54 citations in OpenAlex.
- How a replication origin and matrix attachment region accelerate gene amplification under replication stress in mammalian cells.PloS one · 2014Article
- Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability.Genes, chromosomes & cancer · 2013Article
- Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.PloS one · 2013Article
- Initiation of genome instability and preneoplastic processes through loss of Fhit expression.PLoS genetics · 2012Article
- Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution.BMC evolutionary biology · 2009Article
- Fragile sites in human and Macaca fascicularis chromosomes are breakpoints in chromosome evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Article
- Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.Molecular and cellular biology · 2000Article
- Aphidicolin-inducible common fragile-site expression: results from a population survey of twins.American journal of human genetics · 1992Article
- Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fragile sites on murine chromosomes were induced by the antimetabolites methotrexate (MTX), fluorodeoxyuridine (FdU), and aphidicolin (APD). To facilitate chromosome identification the analysis was performed on chromosomes of a CD/CD mouse that possesses nine pairs of Robertsonian translocation chromosomes of known arm composition. The pattern of induced fragile sites was rather similar for the different antimetabolites used. Many of them, e.g., 2B, 3B, 5B and 9D, are included in Giemsa-negative bands. On the X chromosome a fragile site was mapped to the region XC/D. Comparative mapping data with human fragile sites have been informative in most instances. Conservation of synteny within known linkage groups seems very likely.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.