Evidence map›Paper›PMID 36538525›Full record

ArticlePloS one2022

Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians.

Juan Emmanuel Dewez, Lucy Pembrey, Ruud G Nijman, Stefano Del Torso, Zachi Grossman, Adamos Hadjipanayis, Diego Van Esso, Emma Lim, Marieke Emonts, James Burns and 44 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors at 18 institutions in 22 countries.

Juan Emmanuel DewezClinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-5677-8968
Lucy PembreyDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ruud G NijmanPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Stefano Del TorsoChildCare WorldWide, Padova, Italy.
Zachi GrossmanEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Adamos HadjipanayisEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Diego Van EssoEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Emma LimPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Marieke EmontsPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
James BurnsDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Christèle Gras-LeGuenCentre d'Investigation Clinique CIC1413, INSERM-Nantes University Hospital, Nantes, France.
Daniela KohlfuerstPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).ORCID 0000-0002-1188-9525
Hans Jürgen DornbuschEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Karen Brengel-PescePersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Francois MalletPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Ulrich von BothPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).ORCID 0000-0001-8411-1071
Maria TsoliaPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Irini EleftheriouPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Dace ZavadskaPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Ronald de GrootPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Michiel van der FlierPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Henriëtte MollPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Nienke HagedoornPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).ORCID 0000-0001-9237-4904
Dorine BorensztajnPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Rianne OostenbrinkResearch in European Paediatric Emergency Medicine (REPEM).ORCID 0000-0001-7919-8934
Taco KuijpersPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Marko PokornPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Katarina VincekPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Federico Martinón-TorresPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Irene RiveroPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Philipp AgyemanPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Enitan D CarrolPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Stéphane PaulusPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Aubrey CunningtonPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Jethro HerbergPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Michael LevinPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Aida MujkićEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).ORCID 0000-0002-1795-8229
Karin GeitmannEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Liviana Da DaltResearch in European Paediatric Emergency Medicine (REPEM).
Arūnas ValiulisEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Risto LapattoEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Garyfallia SyridouEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Péter AltorjaiEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Paul TorpianoEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Ketil StørdalEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Károly IllyEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Artur MazurEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Mateja Vintar SpreitzerEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Joana RiosEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Corinne WyderEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Ivanna RomankevychEuropean Academy of Paediatrics Research in Ambulatory Settings network (EAPRASnet).
Romain BasmaciPersonalised Risk Assessment in Febrile Illness to Optimise Real-Life Management Across the European Union (PERFORM).
Salvador Ibanez-MicoHospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Shunmay YeungClinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-0997-0850
European Union · BEEuropean Academy of Technology and Innovation Assessment · DELondon School of Hygiene & Tropical Medicine · GBErasmus MC - Sophia Children’s Hospital · NLEuropean University Cyprus · CYFernUniversität in Hagen · DEHelsinki University Hospital · FIHospital Universitario Virgen de la Arrixaca · ESHungarian National Blood Transfusion Service · HUInserm · FRMaccabi Healthcare Services · ILMater Dei Hospital · MTMedical University of Graz · ATNederlandse Vereniging voor Kindergeneeskunde · NLUniversity of Bern · CHUniversity of Oslo · NOUniversity of Zagreb · HRVilnius University · LT

Funding

Department of Health 668303Department of Health 848196
6 · The paper itself

Abstract

backgroundPoint-of-care-tests (POCTs) have been advocated to optimise care in patients with infections but their actual use varies. This study aimed to estimate the variability in the adoption of current POCTs by paediatricians across Europe, and to explore the determinants of variability. METHODS AND

findingsA cross-sectional survey was conducted of hospital and primary care paediatricians, recruited through professional networks. Questions focused on the availability and use of currently available POCTs. Data were analysed descriptively and using Median Odds Ratio (MOR) to measure variation between countries. Multilevel regression modelling using changes in the area under the receiver operating characteristic curve of models were used to assess the contribution of individual or workplace versus country level factors, to the observed variation. The commonest POCT was urine dipsticks (UD) which were available to >80% of primary care and hospital paediatricians in 68% (13/19) and 79% (23/29) countries, respectively. Availability of all POCTs varied between countries. In primary care, the country (MOR) varied from 1.61 (95%CI: 1.04-2.58) for lactate to 7.28 (95%CI: 3.04-24.35) for UD. In hospitals, the country MOR varied from 1.37 (95%CI:1.04-1.80) for lactate to 11.93 (95%CI:3.35-72.23) for UD. Most paediatricians in primary care (69%, 795/1154) and hospital (81%, 962/1188) would use a diagnostic test in the case scenario of an infant with undifferentiated fever. Multilevel regression modelling showed that the country of work was more important in predicting both the availability and use of POCTs than individual or workplace characteristics.

conclusionThere is substantial variability in the adoption of POCTs for the management of acute infections in children across Europe. To inform future implementation of both existing and innovative tests, further research is needed to understand what drives the variation between countries, the needs of frontline clinicians, and the role of diagnostic tests in the management of acute childhood infections.

Indexed as

Point-of-Care TestingRapid Diagnostic TestsChildCross-Sectional StudiesHumansInfantLactatesPediatriciansLactates

Identifiers

PMID36538525
PMCPMC9767335
OpenAlexW4312036745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.