Evidence map›Paper›PMID 36538385›Full record

ArticleAJNR. American journal of neuroradiology2022

Clinical Validation and Extension of an Automated, Deep Learning-Based Algorithm for Quantitative Sinus CT Analysis.

C J Massey, L Ramos, D M Beswick, V R Ramakrishnan, S M Humphries

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Artificial intelligence in otolaryngology: current applications, limitations, and future perspectives.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  3. Clinical Applications of Multimodal Artificial Intelligence in Otolaryngology: A State-of-the-Art Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C J MasseyFrom the Department of Otolaryngology-Head and Neck Surgery (C.J.M., L.R., V.R.R.), University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0002-6558-4559
L RamosFrom the Department of Otolaryngology-Head and Neck Surgery (C.J.M., L.R., V.R.R.), University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0003-2980-5243
D M BeswickDepartment of Otolaryngology-Head and Neck Surgery (D.M.B.), University of California-Los Angeles School of Medicine, Los Angeles, California.ORCID 0000-0001-8612-5442
V R RamakrishnanFrom the Department of Otolaryngology-Head and Neck Surgery (C.J.M., L.R., V.R.R.), University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0003-2748-0705
S M HumphriesQuantitative Imaging Laboratory (S.M.H.), Department of Radiology, National Jewish Health, Denver, Colorado humphriess@NJHealth.org.ORCID 0000-0002-5113-4530

Funding

Role of taste signaling in airway epithelial functionK23DC014747 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI RAMAKRISHNAN, VIJAY · 2015 to 2020
$1.2M
NIDCD NIH HHS K23 DC014747
6 · The paper itself

Abstract

background and purposeSinus CT is critically important for the diagnosis of chronic rhinosinusitis. While CT is sensitive for detecting mucosal disease, automated methods for objective quantification of sinus opacification are lacking. We describe new measurements and further clinical validation of automated CT analysis using a convolutional neural network in a chronic rhinosinusitis population. This technology produces volumetric segmentations that permit calculation of percentage sinus opacification, mean Hounsfield units of opacities, and percentage of osteitis. MATERIALS AND

methodsDemographic and clinical data were collected retrospectively from adult patients with chronic rhinosinusitis, including serum eosinophil count, Lund-Kennedy endoscopic scores, and the SinoNasal Outcomes Test-22. CT scans were scored using the Lund-Mackay score and the Global Osteitis Scoring Scale. CT images were automatically segmented and analyzed for percentage opacification, mean Hounsfield unit of opacities, and percentage osteitis. These readouts were correlated with visual scoring systems and with disease parameters using the Spearman

resultsEighty-eight subjects were included. The algorithm successfully segmented 100% of scans and calculated features in a diverse population with CT images obtained on different scanners. A strong correlation existed between percentage opacification and the Lund-Mackay score (

conclusionsOur quantitative processing of sinus CT images provides objective measures that correspond well to established visual scoring methods. While automation is a clear benefit here, validation may be needed in a prospective, multi-institutional setting.

Indexed as

Deep LearningOsteitisRhinitisSinusitisAdultAlgorithmsChronic DiseaseHumansProspective StudiesRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID36538385
PMCPMC9451634

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.